Understanding how the molecular machinery of the cell assembles, functions, and evolves
Welcome! We are an interdisciplinary group interested in understanding how molecular machines have evolved, and how they work. To achieve this, we image their structures in the cell using 3-D electron microscopy, and contextualise this structural data against their evolutionary history by analyzing the sequences of their component proteins. Together this enables us to describe how they work, and the forces driving their evolution.
The lab is based at the South Kensington Campus of Imperial College London.
Bacterial flagellar diversity
Bacterial cell vitrofied for electron cryo-tomography
Campylobacter jejuni model
An electron microscope
Electron microscopy grid at low magnification
Lego models of bacterial molecular machines
Salmonella minicells
