We are delighted to be able to inform you of the May MTWC for Fibrosing Lung Disease lecture series seminar talk, which will be held on Thursday 12th May. To this session we will be welcoming at Imperial our speaker Professor Simon Johnson, University of Nottingham.
Talk details as follows:-
Talk Title: mTOR, Lung Proteolysis and Repair in Lymphangioleiomyomatosis
Date: Thursday 12th May
Talk Time: 16:00 – 17:00 UK time
Location: Paul Wood Lecture Theatre, Guy Scadding Building, Brompton Campus, Cale Street, London, SW3 6LY is or Online via Microsoft Teams (you will receive a link to the Lecture once you register)
Please do complete the form in this link to confirm your place – whether attending in person or online.
Further info – Simon Johnson:
Clinical Interests
Respiratory medicine; Interstitial lung disease; Lymphangioleiomyomatosis; Rare lung disease.
Airway remodelling in asthma is categorised by airway smooth muscle hypertrophy and hyperplasia, change in the type and amount of the extra cellular matrix and epithelial shedding and mucous gland hyperplasia. Our interest is how airway proteases and myofibroblast / extra cellular matrix interactions effect myofibroblast growth and behaviour. These studies employ primary airway cell culture, co-cultures, protein expression, functional activity assay real time PCR and proteomics.
Lymphangioleiomyomatosis (LAM) is a rare lung and lymphatic disease categorised by infiltration of smooth muscle type cells in the lungs and lymphatics leading to progressive respiratory impairment. The disease only effects women and is caused by a defect in one of the two proteins associated with tuberous sclerosis, tuberin and hamartin. Our group has a clinical interest in LAM, runs the UK LAM database and is involved in a number of clinical studies and trials.
Laboratory research projects on LAM include the mechanisms of lung destruction in LAM, prognostic biomarkers and the generation of model systems to study LAM.
Matrix metalloproteinases are proteolytic enzymes secreted by a range of cells and regulated by pro-inflammatory cytokines, growth factors, and extra cellular matrix. We have been studying these in airway myofibroblasts and also specific diseases including chronic obstructive pulmonary disease and LAM.
Questions will be taken from those attending in person but if you would like to send a question through before the event please do send to admin.mtwc@imperial.ac.uk
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