Imperial College London
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ProfessorFrankKelly

Faculty of Medicine, School of Public Health

Battcock Chair in Community Health and Policy
 
 
 
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Contact

 

+44 (0)20 7594 8098 ext 48098frank.kelly Website

 
 
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Location

 

Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Barone-Adesi:2015:10.1371/journal.pone.0142565,
author = {Barone-Adesi, F and Dent, JE and Dajnak, D and Beevers, S and Anderson, HR and Kelly, FJ and Cook, DG and Whincup, PH},
doi = {10.1371/journal.pone.0142565},
journal = {PLoS One},
pages = {1--16},
title = {Long-term exposure to primary traffic pollutants and lung function in children: cross-sectional study and meta-analysis},
url = {http://dx.doi.org/10.1371/journal.pone.0142565},
volume = {10},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundThere is widespread concern about the possible health effects of traffic-related air pollution. Nitrogen dioxide (NO2) is a convenient marker of primary pollution. We investigated the associations between lung function and current residential exposure to a range of air pollutants (particularly NO2, NO, NOx and particulate matter) in London children. Moreover, we placed the results for NO2 in context with a meta-analysis of published estimates of the association.Methods and FindingsAssociations between primary traffic pollutants and lung function were investigated in 4884 children aged 9–10 years who participated in the Child Heart and Health Study in England (CHASE). A systematic literature search identified 13 studies eligible for inclusion in a meta-analysis. We combined results from the meta-analysis with the distribution of the values of FEV1 in CHASE to estimate the prevalence of children with abnormal lung function (FEV1<80% of predicted value) expected under different scenarios of NO2 exposure. In CHASE, there were non-significant inverse associations between all pollutants except ozone and both FEV1 and FVC. In the meta-analysis, a 10 μg/m3 increase in NO2 was associated with an 8 ml lower FEV1 (95% CI: -14 to -1 ml; p: 0.016). The observed effect was not modified by a reported asthma diagnosis. On the basis of these results, a 10 μg/m3 increase in NO2 level would translate into a 7% (95% CI: 4% to 12%) increase of the prevalence of children with abnormal lung function.ConclusionsExposure to traffic pollution may cause a small overall reduction in lung function and increase the prevalence of children with clinically relevant declines in lung function.
AU  - Barone-Adesi,F
AU  - Dent,JE
AU  - Dajnak,D
AU  - Beevers,S
AU  - Anderson,HR
AU  - Kelly,FJ
AU  - Cook,DG
AU  - Whincup,PH
DO  - 10.1371/journal.pone.0142565
EP  - 16
PY  - 2015///
SN  - 1932-6203
SP  - 1
TI  - Long-term exposure to primary traffic pollutants and lung function in children: cross-sectional study and meta-analysis
T2  - PLoS One
UR  - http://dx.doi.org/10.1371/journal.pone.0142565
UR  - https://www.ncbi.nlm.nih.gov/pubmed/26619227
UR  - https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0142565
UR  - http://hdl.handle.net/10044/1/81630
VL  - 10
ER  -
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