Imperial College London
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ProfessorFrankKelly

Faculty of Medicine, School of Public Health

Battcock Chair in Community Health and Policy
 
 
 
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Contact

 

+44 (0)20 7594 8098 ext 48098frank.kelly Website

 
 
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Location

 

Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Xu:2023:10.1016/j.envres.2022.115157,
author = {Xu, Z and Jin, J and Yang, T and Wang, Y and Huang, J and Pan, X and Frank, K and Li, G},
doi = {10.1016/j.envres.2022.115157},
journal = {Environmental Research},
title = {Outdoor light at night, genetic predisposition and type 2 diabetes mellitus: a prospective cohort study},
url = {http://dx.doi.org/10.1016/j.envres.2022.115157},
volume = {219},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundAccording to animal and human epidemiologic studies, exposure to outdoor light at night (LAN) may cause circadian disruption, which may disturb sleep quality and lead to incident type 2 diabetes mellitus (T2DM).MethodsWe followed 283,374 persons from 2006 through 2020. Outdoor LAN exposure was estimated using satellite data for individual address with 500 m2 scale buffer during follow-up. Incidence of T2DM was confirmed by hospital inpatient records. We identified potential confounders by a directed acyclic graph, including demographic, genetic, individual and regional level socioeconomic status, and environmental risk factors, and calculated hazard ratios (HRs) and 95% confidence intervals (CIs) through time-varying Cox proportional hazard model. Furthermore, we examined the association of outdoor LAN with a defined health sleep scores and moderation of genetic predisposition and shift work on the relationship of outdoor LAN and incident T2DM.ResultsWe identified 7,775 incident T2DM cases over 3,027,505 person-years. Higher outdoor LAN exposures were significantly associated with higher risk of T2DM. The estimated HR for incident T2DM with an interquartile range (IQR: 11.22 nW/cm2/sr) increase in outdoor LAN was 1.05 (95%CI: 1.01, 1.09) in the fully adjusted model. Participants who lived in the highest quarter of outdoor LAN area were more likely to develop T2DM (HR: 1.14,95%CI: 1.02, 1.27). Besides, those who were exposed to higher levels of outdoor LAN had poorer sleep quality. No moderation role of PRS on outdoor LAN-induced T2DM observed both on the multiplicated and additive scale. The hazards of outdoor LAN were observed in those who never owned a night shift work.ConclusionAlthough further work is required to clarify potential mechanisms, our findings indicate that exposure to residential outdoor LAN may contribute to T2DM risk and low sleep quality.
AU  - Xu,Z
AU  - Jin,J
AU  - Yang,T
AU  - Wang,Y
AU  - Huang,J
AU  - Pan,X
AU  - Frank,K
AU  - Li,G
DO  - 10.1016/j.envres.2022.115157
PY  - 2023///
SN  - 0013-9351
TI  - Outdoor light at night, genetic predisposition and type 2 diabetes mellitus: a prospective cohort study
T2  - Environmental Research
UR  - http://dx.doi.org/10.1016/j.envres.2022.115157
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000913018900001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://www.sciencedirect.com/science/article/pii/S0013935122024847
UR  - http://hdl.handle.net/10044/1/110132
VL  - 219
ER  -
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