Imperial College London
Alternate

ProfessorGeorgePapadakis

Faculty of Engineering, Department of Aeronautics

Professor of Aerodynamics
 
 
 
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Contact

 

+44 (0)20 7594 5080g.papadakis

 
 
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Location

 

331City and Guilds BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Stokes:2023:10.1098/rsif.2023.0281,
author = {Stokes, C and Ahmed, D and Lind, N and Haupt, F and Becker, D and Hamilton, J and Muthurangu, V and von, Tengg-Kobligk H and Papadakis, G and Balabani, S and Díaz-Zuccarini, V},
doi = {10.1098/rsif.2023.0281},
journal = {Journal of the Royal Society Interface},
pages = {1--16},
title = {Aneurysmal growth in type-B aortic dissection: assessing the impact of patient-specific inlet conditions on key haemodynamic indices},
url = {http://dx.doi.org/10.1098/rsif.2023.0281},
volume = {20},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Type-B aortic dissection is a cardiovascular disease in which a tear develops in the intimal layer of the descending aorta, allowing pressurized blood to delaminate the layers of the vessel wall. In medically managed patients, long-term aneurysmal dilatation of the false lumen (FL) is considered virtually inevitable and is associated with poorer disease outcomes. While the pathophysiological mechanisms driving FL dilatation are not yet understood, haemodynamic factors are believed to play a key role. Computational fluid dynamics (CFD) and 4D-flow MRI (4DMR) analyses have revealed correlations between flow helicity, oscillatory wall shear stress and aneurysmal dilatation of the FL. In this study, we compare CFD simulations using a patient-specific, three-dimensional, three-component inlet velocity profile (4D IVP) extracted from 4DMR data against simulations with flow rate-matched uniform and axial velocity profiles that remain widely used in the absence of 4DMR. We also evaluate the influence of measurement errors in 4DMR data by scaling the 4D IVP to the degree of imaging error detected in prior studies. We observe that oscillatory shear and helicity are highly sensitive to inlet velocity distribution and flow volume throughout the FL and conclude that the choice of IVP may greatly affect the future clinical value of simulations.
AU  - Stokes,C
AU  - Ahmed,D
AU  - Lind,N
AU  - Haupt,F
AU  - Becker,D
AU  - Hamilton,J
AU  - Muthurangu,V
AU  - von,Tengg-Kobligk H
AU  - Papadakis,G
AU  - Balabani,S
AU  - Díaz-Zuccarini,V
DO  - 10.1098/rsif.2023.0281
EP  - 16
PY  - 2023///
SN  - 1742-5662
SP  - 1
TI  - Aneurysmal growth in type-B aortic dissection: assessing the impact of patient-specific inlet conditions on key haemodynamic indices
T2  - Journal of the Royal Society Interface
UR  - http://dx.doi.org/10.1098/rsif.2023.0281
UR  - https://www.ncbi.nlm.nih.gov/pubmed/37727072
UR  - https://royalsocietypublishing.org/doi/10.1098/rsif.2023.0281
UR  - http://hdl.handle.net/10044/1/106609
VL  - 20
ER  -
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