Imperial College London
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ProfessorNagyHabib

Faculty of Medicine, Department of Surgery & Cancer

Professor of Hepatobiliary Surgery
 
 
 
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Contact

 

+44 (0)20 3313 8574nagy.habib

 
 
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Assistant

 

Mrs Benita White +44 (0)7960 986 387

 
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Location

 

BN1/18 B BlockHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mizandari:2024:10.3390/jcm13072128,
author = {Mizandari, M and Gotsiridze, E and Keshavarz, P and Nezami, N and Azrumelashvili, T and Nejati, SF and Habib, N and Chiang, J and Raman, SS},
doi = {10.3390/jcm13072128},
journal = {J Clin Med},
title = {Endoportal Radiofrequency Ablation and Stent Placement in Patients with Portal Vein Tumor Thrombosis from Hepatocellular Carcinoma: A Study on Feasibility and Safety.},
url = {http://dx.doi.org/10.3390/jcm13072128},
volume = {13},
year = {2024}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: Hepatocellular carcinoma (HCC) is the most common type of liver cancer, with 10-40% of cases involving portal vein tumor thrombosis (PVTT), leading to poor outcomes and a short survival. The effectiveness of PVTT treatment in patients with HCC is still controversial. Methods: This prospective dual-center study cohort comprised 60 patients with HCC and PVTT who underwent PVR-EPRFA-ST using a novel intravascular radiofrequency system followed by vascular stent placement across the PVTT stenosed segment under fluoroscopy guidance. Results: PVR-EPRFA-ST was technically and clinically successful in 54/60 (90%) and 37/54 (68.5%) patients, respectively. The mean tumor size, PVTT length, post-ablation luminal diameter, and median duration of the recanalized PV patency were 8.6 ± 3.4 cm, 4.1 ± 2.1 cm, 10.3 ± 1.8 mm, and 13.4 months. Higher technical and clinical success rates were associated with a longer survival (177 ± 17.3 days, HR: 0.3, 95%CI 0.12-0.71, p = 0.04; and 233 ± 18.3 days, HR: 0.14, 0.07-0.27, p < 0.001). A shorter survival was associated with Child-Pugh C (HR: 2.7, p = 0.04), multiple tumors (HR: 1.81, p = 0.03), and PVTT length (HR: 1.16, p = 0.04). Conclusions: PVR-EPRFA-ST was feasible and effective for the treatment of selected patients with PVTT, especially in patients with Child-Pugh A/B, single tumors, or a shorter PVTT length.
AU  - Mizandari,M
AU  - Gotsiridze,E
AU  - Keshavarz,P
AU  - Nezami,N
AU  - Azrumelashvili,T
AU  - Nejati,SF
AU  - Habib,N
AU  - Chiang,J
AU  - Raman,SS
DO  - 10.3390/jcm13072128
PY  - 2024///
SN  - 2077-0383
TI  - Endoportal Radiofrequency Ablation and Stent Placement in Patients with Portal Vein Tumor Thrombosis from Hepatocellular Carcinoma: A Study on Feasibility and Safety.
T2  - J Clin Med
UR  - http://dx.doi.org/10.3390/jcm13072128
UR  - https://www.ncbi.nlm.nih.gov/pubmed/38610893
VL  - 13
ER  -
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