Imperial College London
Alternate

ProfessorSaraRankin

Faculty of Medicine, National Heart & Lung Institute

Professor of Leukocyte and Stem Cell Biology
 
 
 
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Contact

 

+44 (0)20 7594 3172s.rankin

 
 
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Assistant

 

Ms Georgina Moss +44 (0)20 7594 2151

 
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Location

 

Office no. 351Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Heyraud:2023:10.3389/fbioe.2023.1224596,
author = {Heyraud, A and Tallia, F and Sory, D and Ting, H-K and Tchorzewska, A and Liu, J and Pilsworth, HL and Lee, PD and Hanna, JV and Rankin, SM and Jones, JR},
doi = {10.3389/fbioe.2023.1224596},
journal = {Frontiers in Bioengineering and Biotechnology},
pages = {1--18},
title = {3D printed hybrid scaffolds for bone regeneration using calcium methoxyethoxide as a calcium source},
url = {http://dx.doi.org/10.3389/fbioe.2023.1224596},
volume = {11},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Introduction: Hybrids consist of inorganic and organic co-networks that are indistinguishable above the nanoscale, which can lead to unprecedented combinations of properties, such as high toughness and controlled degradation.Methods: We present 3D printed bioactive hybrid scaffolds for bone regeneration, produced by incorporating calcium into our “Bouncy Bioglass”, using calcium methoxyethoxide (CME) as the calcium precursor. SiO2-CaOCME/PTHF/PCL-diCOOH hybrid “inks” for additive manufacturing (Direct Ink Writing) were optimised for synergy of mechanical properties and open interconnected pore channels.Results and Discussion: Adding calcium improved printability. Changing calcium content (5, 10, 20, 30, and 40 mol.%) of the SiO2-CaOCME/PTHF/PCL-diCOOH hybrids affected printability and mechanical properties of the lattice-like scaffolds. Hybrids containing 30 mol.% calcium in the inorganic network (70S30CCME-CL) printed with 500 µm channels and 100 µm strut size achieved the highest strength (0.90 ± 0.23 MPa) and modulus of toughness (0.22 ± 0.04 MPa). These values were higher than Ca-free SiO2/PTHF/PCL-diCOOH hybrids (0.36 ± 0.14 MPa strength and 0.06 ± 0.01 MPa toughness modulus). Over a period of 90 days of immersion in simulated body fluid (SBF), the 70S30CCME-CL hybrids also kept a stable strain to failure (∼30 %) and formed hydroxycarbonate apatite within three days. The extracts released by the 70S30CCME-CL hybrids in growth medium did not cause cytotoxic effects on human bone marrow stromal cells over 24 h of culture.
AU  - Heyraud,A
AU  - Tallia,F
AU  - Sory,D
AU  - Ting,H-K
AU  - Tchorzewska,A
AU  - Liu,J
AU  - Pilsworth,HL
AU  - Lee,PD
AU  - Hanna,JV
AU  - Rankin,SM
AU  - Jones,JR
DO  - 10.3389/fbioe.2023.1224596
EP  - 18
PY  - 2023///
SN  - 2296-4185
SP  - 1
TI  - 3D printed hybrid scaffolds for bone regeneration using calcium methoxyethoxide as a calcium source
T2  - Frontiers in Bioengineering and Biotechnology
UR  - http://dx.doi.org/10.3389/fbioe.2023.1224596
UR  - https://www.frontiersin.org/articles/10.3389/fbioe.2023.1224596/full
UR  - http://hdl.handle.net/10044/1/105810
VL  - 11
ER  -
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