PhD Research Students
- Osama Omar M. Fallata
- Joana Santos
- Sophie Zemenides
- Symeon Savvopoulos (Simon)
- Robert J. MacFarlane
- Susana Brito dos Santos
- Asma Abdulaziz Tahlawi
- Michail Klontzas
- Tamador Alsobaie
- António Lima Grilo
Nationality: Saudi
E-mail: o.fallata06@imperial.ac.uk
Office: ACEX Room 1M4, Chemical Engineering Dept., South Kensington Campus.
Office Tel: +44 (0)20 7594 1224
Supervisors: Dr. Nicki Panoskaltsis and Prof. Mantalaris
Research interests:
Ex vivo expansion of Umbilical Cord Blood (CB) Haematopoietic stem Cells through the biomimicary of the haematopoietic bone marrow niche in a 3D scaffold and with a highly controlled environment afforded by the bioreactor system. The project involves:
- Use of Design of Experiments (DOE) for the identification of important parameters/factors in the growth and expansion of HSCs.
- Reconstruction of 3D BM niches using the factors identified in DOE.
- Comparison of 3D versus 2D culture systems using the critical factors identified by DOE.
- Evaluation and optimisation of the bioprocess for HSC cultivation and expansion within a bioreactor using the best system identified above.
Biography
| Date | Role |
|---|---|
| 2007-Present | PhD in Clinical Investigative Sciences, Haematology Department, Imperial College London, UK. |
| 2005-2006 | MSc in Developmental Cell Biology, University of Sussex, UK. |
| 2005-2012 | Resident Physician at King Fahad Medical City(sponsor), Riyadh, Saudi Arabia. |
| 2003-2004 | House Officer: inpatient clinics, outpatient clinics, operating theatre, and emergency and on-call duties. |
| 2003 | M.B.B.S King Abdulaziz University, Faculty of Medicine, Jeddah, Saudi Arabia |
Research title
Bioprocessing of Haematopoietic Stem Cells (HSCs)
Award/Funding
Funding provided by the King Fahad Medical City, Riyadh, Saudi Arabia.
Nationality: Portugese
E-mail: joana.dos-santos14@imperial.ac.uk
Office: Room 1M4 ACEX Building
Office Tel: +44 (0) 2075941224
Supervisors: Dr. Nicki Panoskaltsis & Prof. A. Mantalaris
Research Interests:
- Ex vivo culture of leukemic cells
Nationality: British
E-mail: s.zemenides@imperial.ac.uk
Office: Room 1M5 ACEX Building
Office Tel: +44 (0) 2075941224
Supervisors: Dr. Nicki Panoskaltsis & Prof. A. Mantalaris
Research Interests:
- Acute Myeloid Leukemia
Nationality: Greek
E-mail: s.savvopoulos@imperial.ac.uk
Office: Room c509, Roderic Hill building, Centre for Process Systems Engineering,Department of Chemical Engineering.
Office Tel: +44 (0)7411 646 6362
Supervisors: Prof. Sakis Mantalaris and Dr Nicki Panoskaltsis
Research Interests:
- Cell cycle analysis
- Pharmacokinetics and pharmacodynamics
- Drug delivery systems
Biography
| Date | Role |
|---|---|
| 2014-2018 | PhD in Chemical Engineering, Imperial College London, UK. |
| 2011 | Internship in the Centre for Research and Technology-Hellas (CERTH) - “Modeling, design and optimization of desalination processes” |
| 2006-2012 | 5-year Diploma in Chemical Engineering, Aristotle University of Thessaloniki, Greece. |
Research title
Mathematical modelling of chronic lymphocytic leukaemia
Publications / Presentations
- Publications
- S. V. Savvopoulos, R. Misener, N. Panoskaltsis, E. N. Pistikopoulos, A Mantalaris, Global Sensitivity Analysis for a Dynamic Model of Chronic Lymphocytic Leukemia Disease Trajectories, 12th International Symposium on Process Systems Engineering and 25th European Symposium on Computer Aided Process Engineering, volume 37, pp.185 - 190, 2015
- S. V. Savvopoulos, R. Misener, N. Panoskaltsis, E.N. Pistikopoulos, A. Mantalaris, A Personalized Framework for Dynamic Modeling of Disease Trajectories in Chronic Lymphocytic Leukemia, IEEE Transactions on Biomedical Engineering, 2016, in print.
- Presentations
- S. V. Savvopoulos, R. Misener, N. Panoskaltsis, E. N. Pistikopoulos, A. Mantalaris, Global Sensitivity Analysis for a Dynamic Model of Chronic Lymphocytic Leukemia Disease Trajectories, ESCAPE 25 - PSE 12, Copenhagen, May 2015 (17% acceptance rate for presentation)
- Poster Presentations
- S. V. Savvopoulos, R. Misener, N. Panoskaltsis, E.N. Pistikopoulos, A. Mantalaris, A Personalized Framework for Dynamic Modeling of Chronic Lymphocytic Leukemia, AIChE annual meeting, Atlanta GA, Nov 2014
- M. Fuentes-Garí, S. V. Savvopoulos, R. Misener, D. Garcia-Munzer, M. Kostoglou, M. C. Georgiadis, N. Panoskaltsis, E. N. Pistikopoulos, A. Mantalaris, Towards personalised healthcare engineering: focus on leukaemia, CPSE symposium, Imperial College, December 2014
Others
- Scholarship from Greece (State Scholarship Foundation) as the best student from 2008 to 2009
Nationality: British
E-mail: robert.macfarlane@doctors.org.uk
Office: Room c611a , Roderic Hill building, Centre for Process Systems Engineering,Department of Chemical Engineering.
Office Tel: +44 (0)20 75941205
Supervisors: Prof. Sakis Mantalaris and Prof. Eleftherios Tsiridis
Research Interests:
- Osteogenesis in skeletal tissue engineering
- Bioreactor technology for stem cell bioprocessing
Biography
| Date | Role |
|---|---|
| 2013-present | PhD student in Chemical Engineering, Department of Chemical Engineering and Chemical Technology, Imperial College London, UK |
| 2012 | Masters of Research (MRes) in Medical Technology, University of Strathclyde |
| 2008 | MRCS Diploma, Royal College of Surgeons of England |
| 1999-2004 | MB ChB Medicine & Surgery, The University of Edinburgh |
Research title
Production of bio-inspired 3D mineralised cellular implants for bone tissue engineering applications
Publications/Presentations
- MacFarlane RJ, Konan S, El Husseiny M, Haddad FS. Outcomes following the surgical management of femoroacetabular impingement. Ann Royal Coll Surg 2014 (in press)
- MacFarlane RJ, Russo A. Improving exposure in posterior cervical surgery: The elastoplasty. Ann Royal Coll Surg 2014 (in press)
- Mehta N, MacFarlane RJ, Brown DJ. Traumatic disorders of forearm rotation: pathoanatomy, biomechanics and treatment. Br J Hosp Med 2014;75(2):72-77
- Macfarlane RJ, Waseem M. Editorial: Current Concepts and Recent Developments in Shoulder Surgery. Open Orthop J. 2013 Sep 6;7:304.
- Akhtar A, Macfarlane RJ, Waseem M. Pre-Operative Assessment and Post-Operative Care in Elective Shoulder Surgery. Open Orthop J. 2013 Sep 6;7:316-322.
- Nagy MT, Macfarlane RJ, Khan Y, Waseem M. The Frozen Shoulder: Myths and Realities. Open Orthop J. 2013 Sep 6;7:352-355.
- Widnall JC, Dheerendra SK, Macfarlane RJ, Waseem M. The Use of Shoulder Hemiarthroplasty and Humeral Head Resurfacing: A Review of Current Concepts. Open Orthop J. 2013 Sep 6;7:334-337.
- Sulaiman L, Macfarlane RJ, Waseem M. Current Concepts in Anaesthesia for Shoulder Surgery. Open Orthop J. 2013 Sep 6;7:323-328.
- Donnelly TD, Ashwin S, Macfarlane RJ, Waseem M. Clinical Assessment of the Shoulder. Open Orthop J. 2013 Sep 6;7:310-315. PMID: 24082969
- Iqbal S, Jacobs U, Akhtar A, Macfarlane RJ, Waseem M. A History of Shoulder Surgery. Open Orthop J. 2013 Sep 6;7:305-309.
- MacFarlane RJ, Graham SM, Davies P, Korres N, Mantalaris A, Tsiridis E. Anti-Inflammatory Role and Immunomodulation of Mesenchymal Stem Cells in Systemic Joint Diseases: Potential for Treatment. Expert Opin Ther Targ 2013;17(3):243-54
- Davies PS, Graham SM, MacFarlane RJ, Leonidou A, Mantalaris A, Tsiridis E. Disease-modifying osteoarthritis drugs: in vitro and in vivo data on the development of DMOADs under investigation. Expert Opin Investig Drugs. 2013 Apr;22(4):423-41.
- Gillespie S, Cashin F, Macfarlane RJ, Brown DJ. Prevention of extension lag using a sling attachment for ligamentotaxor devices in complex PIPJ injuries. Ann R Coll Surg Engl. 2012 Jul;94(5):367-8.
- El-Husseiny M, Patel S, Macfarlane RJ, Haddad FS. Biodegradable Antibiotic Delivery Systems: Where are we now? Journal of Bone and Joint Surgery (Br) 2011;93(2):151-157
- Macfarlane RJ. Haddad F S. The Diagnosis and Management of Femoro-acetabular Impingement. Annals of the Royal College of Surgeons 2010 Jul;92(5):363-7
- Macfarlane RJ, Ali Z, Datt, D, Venkateswaran B. Healing of the greater tuberosity in acute shoulder hemiarthroplasty using an accelerated rehabilitation regime. Shoulder and Elbow 2010;2:131-135
- Macfarlane RJ, Hadi S, Binns M. Trochanteric Bursitis in association with Increased Offset Femoral Stem Components in Total Hip Arthroplasty. Journal of Bone and Joint Surgery proceedings (Br) 2010
- Macfarlane R J, Ng B, Velonis S, Tsiridis E. Pharmacological Treatment of Heterotopic Ossification Following Hip and Acetabular Surgery. Expert Opinion in Pharmacotherapy 2008;9(5):1-19
Teaching
- Clinical Lecturer in Applied Surgical Anatomy, King’s College London (GKT Medical School), 2013-present.
- Clinical Tutor in Trauma and Orthopaedic Surgery, University of Liverpool 2010-2013.
- Special Study Module tutor in Orthopaedic Surgery, University College Hospital, London, 2009.
- Honorary Anatomy Demonstrator, King’s College London (GKT Medical School), 2007.
Awards/funding
- Royal College of Surgeons Surgical Research Fellowship, 2013-present
Others
- Currently holds a National Training Number (NTN) in Trauma and Orthopaedic Surgery – special interest: hand and upper limb surgery
- Has presented a range of clinical studies at national and international conferences in orthopaedic surgery including in London, Manchester, Madrid, Istanbul, Delhi and Bangalore
- 3rd poster prize at Mersey Orthopaedic Registrar’s Conference 2012
- University of Strathclyde CTA Studentship award, 2008-10
Nationality: Portuguese
E-mail: susana.brito-dos-santos13@imperial.ac.uk
Office: ACEX Room 1M4, Chemical Engineering Dept., South Kensington Campus
Office Tel: +44 (0)20 7594 1224
Supervisors: Prof. Sakis Mantalaris and Dr. Nicki Panoskaltsis
Research Interests:
- Scaffold technology for stem cell and leukemic cell bioprocessing
- In vitro red blood cell production
- Biochemical and microenvironmental factors involved in red blood cell production
Biography
| Date | Role |
|---|---|
| 2014-present | PhD student in Chemical Engineering, Department of Chemical Engineering and Chemical Technology, Imperial College London, UK. Master thesis development at BSEL, Department of Chemical Engineering, Imperial College London, UK. |
| 2013 | Title: “Growth and cell cycle kinetics of AML and CLL cell lines in a 3D bone marrow biomimicry under oxidative and starvation stresses” MSc. in Bioengineering, Marmara University, Istanbul, Turkey |
| 2011-2013 | MSc. in Biological Engineering, Instituto Superior Técnico, Lisbon, Portugal |
| 2008-2011 | BSc. in Biological Engineering, Instituto Superior Técnico, Lisbon, Portugal |
Research title
In vitro erythropoiesis: reproducing in vivo biochemical and microenvironmental factors involved in red blood cell formation
Publications/Presentations
Presentations
- M. Fuentes-Gari, E. Velliou, R. Misener, S. Brito Dos Santos, N. Panoskaltsis, A. Mantalaris and E. N. Pistikopoulos. “Towards a personalised treatment of acute myeloid leukaemia: the impact of considering the cell cycle”. AIChE annual meeting, San Francisco, November 2013
- M. Fuentes-Gari, E. Velliou, R. Misener, S. Brito Dos Santos, N. Panoskaltsis, A. Mantalaris and E. N. Pistikopoulos. “From in vitro to in silico: cell cycle kinetics of acute myeloid leukemia cells”. Young Researchers Meeting, IChemE, Birmingham, September 2013
Poster Presentation
- E. Velliou, M. Fuentes Gari, S. Brito Dos Santos, R. Misener N. Panoskaltsis, A. Mantalaris, E. N. Pistikopoulos “The effect of oxygen and glucose stress on the evolution of a leukaemia model system in an in vitro bone marrow mimicry”. AIChE Annual Meeting, San Francisco, November 2013.
Awards/Funding
- 2014-2017: ERC - BioBlood
Others
Work Experience
- October 2009-October 2010: Grant for integration in research in IBB/Instituto Superior Técnico, Technical University of Lisbon, Bioengineering Research Group
- Project: Production and Purification of pDNA: optimization of bacterial cell lysis using a sonication technique combined with a DNA condensing agent to obtain plasmids.
Others
- Merit Scholarship from Instituto Superior Técnico for the academic year of 2010/2011
- Diploma of Merit from Instituto Superior Técnico for the academic year of 2008/2009
- Scholarship from Portuguese Ministry of Education for merit performance in the Secondary School (2008)
Nationality: Saudi
E-mail: a.tahlawi13@imperial.ac.uk
Office: Room C611a, Roderic Hill building, Centre for Process Systems Engineering, Department of Chemical Engineering.
Office Tel: +44 (0) 2075941224
Supervisors: Prof. Sakis Mantalaris and Prof. Kang Li
Research Interests:
- Bioreactor engineering
- Material fabrication and modification for targeted applications
Biography
| Date | Role |
|---|---|
| 2013-present | Ph.D. Chemical Engineering, Imperial College London, United Kingdom |
| 2007-2013 | Saudi Aramco Oil Company |
| 2006-2007 | MSc. Biotechnology, Department of Chemical Engineering & Analytical Sciences, University of Manchester, United Kingdom |
| 2004-2006 | Saudi Aramco Oil Company |
| 2000-2004 | BSc. Chemical Engineering, American University of Sharjah, United Arab Emirates |
Research title
Development of a Three-Dimensional Bone Marrow Bio-mimicry.
Publications/Presentations
Conference Proceedings and Poster:
- J. W. Jones1, M. Lorch3, A. Tahlawi2 and G. J. T. Tiddy2 , Hysteresis in density measurements of DPPC/ DOPC lipid mixtures and the effect of the membrane protein diacylglycerolkinase, Faraday Discussions no 161-titled "Lipids and Biomembranes", Sep 2012.
Awards/Funding
- 2006: MSc. Full-time scholarship from the ministry of Higher Education in Saudi Arabia
- 2013: PhD Full-time scholarship, Saudi Aramco Oil Company.
Nationality: Greek
E-mail: m.klontzas14@imperial.ac.uk
Office: Room 1M4, ACEX Building, Department of Chemical Engineering.
Office Tel: +44 (0) 2075941224
Supervisors:Prof. Sakis Mantalaris , Prof. Eleftherios Tsiridis, Mr Manolis Heliotis
Research Interests:
- Bone and Cartilage Tissue Engineering
- Metabolomics
Biography
| Date | Role |
|---|---|
| Oct. 2015 - now. | Marie Curie Early Stage Researcher - SymBioSys ITN, Imperial College London, UK. |
| 2012-2014 | Department of Medical Imaging, University of Crete, Musculoskeletal MR imaging. Head: Prof. Apostolos H. Karantanas. |
| 2010-2013 | Hemopoiesis Research Laboratory, University of Crete, Greece. Head: Prof. Helen A. Papadaki. |
| 2008-2014 | Medical Degree (MD), First class honours, University of Crete, Greece. |
Selected Publications
For the full list please refer to the Professional Webpage and Google Scholar
Peer-reviewed journal articles
- Klontzas ME, Vernardis SI, Heliotis M, Tsiridis E, Mantalaris A, Metabolomics analysis of the osteogenic differentiation of umbilical cord blood mesenchymal stem cells reveals differential sensitivity to osteogenic agents, Stem Cells Dev 2017; 26(10): 723-733
- Kang Y, Georgiou AI, MacFarlane RJ, Klontzas ME, Heliotis M, Tsiridis E, Mantalaris A, Fibronectin stimulates the osteogenic differentiation of murine embryonic stem cells, J Tissue Eng Regen Med 2015; Epub ahead of print; doi: 10.1002/term.2090
- Klontzas ME, Zibis AH, Karantanas AH, Osteoid osteoma of the femoral neck: use of the half-moon sign in MRI diagnosis, AJR AM J Roentgenol 2015; 205(2):353-357
- Klontzas ME, Kenanidis EI, Heliotis M, Tsiridis E, Mantalaris A, Bone and cartilage regeneration with the use of umbilical cord mesenchymal stem cells, Expert Opin Biol Ther 2015;15(11):1541-52
- Klontzas ME, Vassalou EE, Zibis AH, Bintoudi AS, Karantanas AH, MR imaging of transient osteoporosis of the hip: An update on 155 hip joints, Eur J Radiol 2015; 84(3)431-436
Book chapters
- Klontzas ME, Kramer J, Karantanas AH, The many faces of hip bone marrow edema, in: “MRI of the hip”, Kramer J, Karantanas AH (Eds.), ESSR Sports Imaging Subcommittee, Vienna, Breitenseher Publisher, 2016
Nationality: Saudi
E-mail: t.alsobaie11@imperial.ac.uk
Office: Room c611a, Roderic Hill building, Centre for Process Systems Engineering, Department of Chemical Engineering.
Office Tel: +44 (0) 2075941224
Supervisors: Prof. Mantalaris
Research Interests:
- Human Induced Pluripotent Stem Cells
- Bioreactor technology for stem cell bioprocessing
Biography
| Date | Role |
|---|---|
| 2013-present | PhD. Chemical Engineering, Imperial College London, United Kingdom. |
| 2006-2012 | Premarital Screening Tests, King Salman Hospital, Saudi Arabia. |
| 2005-2006 | Internship, King Faisal Hospital & Research Centre, Saudi Arabia. |
| 2001-2005 | BSc. Biotechnology, King Saud University, Saudi Arabia. |
Research title
Generation of Lung Epithelium from hIPS Cells in 3D Dynamic Culture
Awards/Funding
- 2013: PhD Full-Time scholarship from the Ministry of Higher Education in Saudi Arabia
| Date | Role |
|---|---|
| 2016 - present | PhD in Chemical Engineering Imperial College London |
| 2015-2016 |
MSc. Petroleum Engineering Heriot-Watt University Thesis: Determination of optimal drilling sequences and their impact in asset production concepts and economics. |
| 2013 - 2014 | Research Assistant in BioSeparations, Institute of BioEngineering and BioSciences, Instituto Superior Técnico, Lisbon, Portugal |
| 2013 | MSc. Co-op student in Purification Process Development at Amgen, Inc., Seattle, WA, USA |
| 2008 - 2013 |
MSc. Biochemical Engineering, Instituto Superior Técnico, Lisbon, Portugal Thesis: Aqueous Two-Phase Systems for Large Scale Purification of Monoclonal Antibodies |
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- Galvão, A.M.; Carvalho, M.F.N.N and Grilo, A.L.: (2014) Supramolecular arrangement promoted in trans-[PdCl2(OHNC10H14I)2].2H2O by hydrogen bonding. Journal of Molecular Structure. doi:10.1016/j.molstruc.2014.02.054
- Grilo, A.L.; Aires-Barros, R.; Azevedo, A. (2014) Partitioning in Aqueous Two-Phase Systems: Fundamentals, Applications and Trends. Separation and Purification Reviews. doi:10.1080/15422119.2014.983128
- Taipa, M.A; Azevedo, A. M.; Grilo, A.L.; Couto, P.T.; Ferreira, F.A.G.; Fortuna, A. R. M.; Pinto, I.F.; Santos, R.M.; Santos, S. B. (2015) Student collaboration in a series of integrated experiments to study enzyme reactor modelling with immobilized cell-based invertase. J. Chem. Edu. doi:10.1021/ed500842p
- Vedantham, G.; Piper, R. Grilo, A.; Lacki, K.; VanAlstine, J.; (2013) Investigation of alternative separation technologies for the harvest of CHO cell culture. 17th International Conference on BioPartioning and Purification.
- Grilo, A.L.; Carvalho, M.F.N.N.(2011): “Moving from inner to outer sphere via hydrogen bridging”. Poster presentation at the XXII Meeting of the Portuguese Chemical Society.
Contact details
Professor Sakis Mantalaris
Head of BSEL Group
Chemical Engineering Department
Tel: +44 (0)20 7594 5601
Email:
a.mantalaris@imperial.ac.uk