Gathered here is a list of resources for researchers, as well as toolkits and useful applications. Find out more via the links below:
Resources and tools
Allen Brain Atlas
As part of a 10-year plan launched in March 2012 to understand the neural code - how activity in the brain's cortex leads to perception, decision making, and ultimately action - the Allen Institute has created a set of large-scale programs to understand the fundamentals of the cortex.
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Alzforum - Networking for a cure
Founded in 1996, Alzforum is a news website and information resource dedicated to helping researchers accelerate discovery and advance the development of diagnostics and treatments for Alzheimer’s disease and related disorders.
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Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART)
ISTAART is a professional society for individuals interested in Alzheimer's and dementia science - including scientists, physicians and other professionals involved in the causes and treatments of Alzheimer's disease and other dementias.
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Brain RNA-Seq
RNA-Seq of cell types isolated from mouse and human brain.
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COEN Initiative (Network of Centres of Excellence in Neurodegeneration)
The overall aim of the COEN initiative is to build collaborative research activity in neurodegeneration research across borders, focusing on the critical mass and excellence. COEN is aligned with the broader European Joint Programming Initiative in Neurodegeneration.
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DANA Foundation - Your gateway to responsible information about the brain
The Dana Foundation is a private philanthropic organization that supports brain research through grants, publications, and educational programs.
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Dementias Platform UK (Medical Research Council)
A public-private partnership that gives unprecedented access to the detailed information concerning health, family history, and lifestyle for over 2 million individuals from over 40 cohort studies, including large, longitudinal population-based studies. It has been created by MRC to facilitate and accelerate the discovery of new ways to understand, diagnose, and treat dementia.
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EU Joint Programme – Neurodegenerative Disease Research (JPND)
The JPND aims to increase coordinated investment between participating countries in research aimed at finding causes, developing cures, and identifying appropriate ways to care for those with neurodegenerative diseases.
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Expression Atlas
An open science resource that gives users a powerful way to find information about gene and protein expression across species and biological conditions such as different tissues, cell types, developmental stages and diseases among others. Expression Atlas aims to help to answer questions such as ‘where is a certain gene expressed?’ or ‘how does its expression change in a disease?’
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HBT (Human Brain Transcriptome) Project
The HBT project at the Department of Neurobiology Yale University School of Medicine is a public database containing transcriptome data and associated metadata for the developing and adult human brain.
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HMDB (The Human Metabolome Database)
The HMDB is a freely available electronic database containing detailed information about small molecule metabolites found in the human body. It is intended to be used for applications in metabolomics, clinical chemistry, biomarker discovery and general education.
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Home Office
The Home Office offers Personal Licensee Training in Legislation & Ethics as well as theory behind relevant procedures (PIL Modules A–C), which is now available online with Charles River UK.
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How’s and Whys of Writing Research Grants and Fellowship ApplicationsHuman Protein Atlas
A joint UK DRI Centre at Imperial/ Department of Brain Sciences. A series of short practical talks to help you better prepare for grant and fellowship applications open to everyone.
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Seminar Series A Swedish-based program initiated in 2003 with the aim to map all the human proteins in cells, tissues and organs using integration of various omics technologies, including antibody-based imaging, mass spectrometry-based proteomics, transcriptomics and systems biology.
Join Dementia Research
People with dementia or memory problems, their carers and anyone who is interested can register their interest in participating in dementia research. You can also sign up for someone else, providing that you have their consent.
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Mouseac
A tool from the Mouse Dementia Network, University College London (Mouse DemNet UCL), investigating gene expression changes in a number of mouse models of dementia across their lifespan relating to neurodegenerative disorders.
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Single-cell RNAseq profiles for microglia and brain myeloid cells (1816 cells total passed quality control) from different developmental stages (E14.5, P7 and P60). Cells were isolated from either the whole developing brain (E14.5) or one of the six regions (P7 and P60): Cortex, Cerebellum, Hippocampus, Striatum, Olfactory bulb, Choroid plexus.
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National Alzheimer's Coordinating Center
Established in 1999, the National Alzheimer’s Coordinating Center holds a large database of standardised clinical and neuropathological research data. This data is freely available to all researchers.
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Nature Neuroscience Reviews
A collection of Reviews on recent advances in neurodegenerative disease, focussing on shared mechanisms across diseases and the gaps in our knowledge that still need to be addressed.
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Neuropathology Review
An excellent Review of neuropathological alterations in Alzheimer's disease published in Cold Spring Harbour Perspectives for Medicine.
Read paper
PheWAS Resources (Phenome-wide association studies)
PheWAS studies analyze many phenotypes compared to a single genetic variant (or other attributes). This method was originally described using electronic medical record (EMR) data from EMR-linked in the Vanderbilt DNA biobank, BioVU, but can also be applied to other richly phenotyped sets.
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PRiMER Articles
Peer-Reviewed Reports in Medical Education Research - two helpful reports for an overview on Alzheimer's and Parkinson's disease.
Read Alzheimer's Primer and an illustrated summary of the article.
Read Parkinson's Primer
What Is Brain Health (NIH)
Launched in 2015, it is a national campaign to help raise awareness about brain health while empowering older adults to make the most of their brains as they age.
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Brain Health Resource (NIH)
The Brain Health Resource is a presentation toolkit offering current, evidence-based information and resources to facilitate conversations with older people about brain health as we age.
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Clinical Trials Toolkit
The Clinical Trials Toolkit provides practical advice to researchers in designing and conducting publicly funded clinical trials in the UK
Healthy Brains
Healthy Brains by Cleveland Clinical is a tool used to provide individualised brain health assessment tools, lifestyle tips and medical news.
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Six basic statistical tools
Statistical guidance from the website of the Food and Agriculture Organization of the United Nations
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Slack
Slack is an online platform that connects teams with apps, services, and resources that can accelerate and improve the progress of their collaborative work.
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The R-Project for Statistical Computing
R is a free software environment for statistical computing and graphics. It compiles and runs on a wide variety of UNIX platforms, Windows and MacOS.
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Corporate Partnerships and Industry Research - Prasshy Jeyarajan, IPC Executive (p.jeyarajan@imperial.ac.uk)
Includes corporate engagement, industry collaborations, commercial research opportunities and business development activities.
Commercialisation, Advanced Therapeutic Medicinal Products (ATMPs) and Vaccines – Neringa Barmute, IPC Executive (n.barmute@imperial.ac.uk), (Maternity Cover for Monika Kraszewska-Hamilton)
Includes gene therapies, somatic cell therapies (e.g., CAR-T, CRISPR), stem cells, tissue engineered medicinal products and vaccines
Commercialisation, Medtech– Sharma Shruti, IPC Executive (shruti.sharma@imperial.ac.uk)
Technology used in care settings including devices (in vitro, diagnostic), diagnostic imaging, drug delivery systems, wound care management, prosthesis, surgical equipment and procedure innovations, implant technology, biomaterials and connected health IT.
Commercialisation, Therapeutics – Jon Wilkinson, IPC Senior Executive (jonathan.wilkinson@imperial.ac.uk)
Treatment therapies including drugs (biologics, small molecules, miRNA etc) and their administration.
Corporate Partnerships and Commercialisation activities - Stephanie Morris, Director IPC FoM (stephanie.morris@imperial.ac.uk).