Research within this theme will produce novel antimicrobial therapeutics which will replace treatments to which resistance is widespread in clinical practice. This theme brings together expertise in antimicrobial synthesis and drug design towards novel targets, target validation, the efficacy of target protein inhibition, and analysis of the effects on bacterial cells. Our researchers are devising parallel synthesis of compounds to provide hit structures for bioassay and optimisation of structure-activity relationships to provide lead compounds for further in vivo studies. These lead compounds will eventually progress into phase-I clinical trials.
Members of the pharmacology and therapeutics theme
Professor Alan Armstrong
Professor Alan Armstrong
Head of Department of Chemistry
Dr Anna Barnard
Dr Anna Barnard
Research Fellow (Sir Henry Dale Fellowship)
Professor Anthony Barrett
Professor Anthony Barrett
Head of Synthesis
Dr Rongjun Chen
Dr Rongjun Chen
Reader in Biomaterials Engineering
Dr Matthew Child
Dr Matthew Child
Research Fellow (Sir Henry Dale Fellow)
Dr Ceire Costelloe
Dr Ceire Costelloe
Career Development Fellow
Dr Tom Ellis
Dr Tom Ellis
Senior Lecturer in Synthetic Biology
Dr Lindsay Evans
Dr Lindsay Evans
Research Associate
Dr Matthew Fuchter
Dr Matthew Fuchter
Reader in Chemistry
Dr John Heap
Dr John Heap
Lecturer in Synthetic Biology
Dr Julie McDonald
Dr Julie McDonald
Research Associate (Metabonomics & Microbiomics)
Professor Alan Spivey
Professor Alan Spivey
Professor of Synthetic Chemistry
Professor Ed Tate
Professor Ed Tate
Professor of Chemical Biology
Professor Martin Wilkins
Professor Martin Wilkins
Head of Department of Medicine
Professor Keith Willison
Professor Keith Willison
Chair in Chemical Biology