PhDs, MRes and MSc projects
The PhD degree is the critical first step on the pathway to a research career. Current PhD projects within the Vasculitis Centre for Research receive funding from a variety of sources including the Wellcome Trust, Medical Research Council, the British Heart Foundation and the Auchi Foundation. They include multi-disciplinary basic science and clinical translational PhD projects.
Members of the Centre of Excellence in Vasculitis Research also lecture on a variety of the Imperial College Masters courses including Immunology, Molecular Medicine, Biomedical Research, Clinical Research, Drug Discovery and Development and Genes, Drugs and Stem Cells.
The Graduate School and Clinical Academic Training Office at Imperial College provides an extensive network of world-class support for postgraduate students:
- Graduate School Support
- Clinical Research Training Fellow (CRTF)
For those interested in pursuing a higher degree please contact members of the Centre and look for opportunities advertised on the website.
Projects
- Investigation of the role of adenosine deaminase 2 in monocyte and endothelial homeostasis and in the pathogenesis of vascular injury
- Biomarker analysis in large vessel vasculitis
- Investigating the relationship between inflammation and the pro-coagulant pathway in ANCA-associated vasculitis
Investigation of the role of adenosine deaminase 2 in monocyte and endothelial homeostasis and in the pathogenesis of vascular injury
Funder: Wellcome Trust
Researcher: Dr Andrew Porter
Supervisors: Professor Justin Mason, Dr Adam Byrne, Dr Taryn Youngstein
Understanding of disease pathogenesis and mechanisms of vascular injury in the vasculitides remains limited, while morbidity and treatment toxicity remains high. In 2014, a monogenic vasculitis was described (DADA2) in which there is a deficiency of the enzyme Adenosine Deaminase 2 (ADA2). This is associated with a syndrome of vascular inflammation affecting small-medium arteries and complicated by digital gangrene and stroke. This phenotype suggests ADA2 is critical for the maintenance of vascular integrity and resistance to endothelial dysfunction, and therefore of relevance to diseases in which vascular injury is implicated. However, the mechanisms through which ADA2 binds to the vascular endothelium and exerts its effects remain unknown. This project will determine the importance of ADA2 by investigating the hypothesis that: (i) ADA2 is critical for monocyte homeostasis and maintenance of the endothelial barrier, and (ii) ADA2 deficiency results in monocyte activation, cytokine synthesis and enhanced adhesion resulting in loss of vascular endothelial integrity. A variety of cell and molecular biology techniques will be applied, including study of patient-derived endothelial cells and monocytes and the functional mechanistic analysis of monocyte:endothelial cell interactions. In Aim 3, the vasculoprotective impact of therapeutic intervention against the deleterious actions of ADA2-deficient monocytes will be determined.
Biomarker analysis in large vessel vasculitis
Researcher: Dr Martha Peverelli
Supervisor:
Investigating the relationship between inflammation and the pro-coagulant pathway in ANCA-associated vasculitis
Researcher: Dr Aruni Ratnayake
Supervisors: Professor Frederick Tam and Dr Tom McKinnon
ANCA-associated vasculitis (AAV) causes glomerulonephritis (GN), which in severe cases results in rapidly progressive kidney injury and life threatening lung haemorrhage. AAV is also associated with increased incidence of systemic arterial and venous thrombosis, raising the risk of ischaemic heart disease, stroke and pulmonary emboli. The mechanisms linking inflammatory processes of AAV and the clotting cascade are poorly understood. I hypothesise that inflammatory processes of AAV activate the procoagulant cascade causing glomerular and systemic thrombosis, with a possible positive feedback loop linking the two processes. Anticoagulation may therefore attenuate renal disease and associated accelerated cardiovascular disease; however there is a caveat, as some of these patients are prone to lung haemorrhage. I shall use multiple experimental approaches to further investigate these interactions, including in vitro study of ANCA or cytokine activated monocytes or neutrophils with endothelial cells under sheer stress, analysis of patients’ samples and intervention studies in vivo. The hope is my work will elucidate characteristics in patients with AAV that increase the rate of thrombus formation and its relationship to inflammation. This will allow clinicians to balance a patient's risk of thrombus formation or lung haemorrhage. If there is crosstalk between the two processes, then anticoagulant medications could be targets for novel therapeutic agents for AAV, reducing inflammation and subsequent end-organ damage.
General enquiries
For any questions related to the Centre, please contact:
Vasculitis Centre of Excellence Admin
VasculitisCoE@imperial.ac.uk