MultifacultyCentre of Cellular Mechanosensing and Functional Microscopy Inaugural Conference

We are pleased to announce the formation of the new Cellular Mechanosensing and Functional Microscopy Centre. The role of this multi-faculty research centre is to promote the diversity of research landscape by establishing new collaborations. 

To celebrate this achievement, we warmly welcome you to join our Inaugural Multifaculty CMFM Centre Conference “Bringing together technology to resolve biological problems “. 

If you’d like to attend in-person, please emails us at CMFM@imperial.ac.uk (limited places) or join online. 

Teams details:
Meeting ID: 398 407 132 254
Passcode: KDfuyu

Programme

9:30-9:40 Welcome and introduction from Julia Gorelik

9:40-10:10 Nanoscale techniques for single molecules detection and cellular applications (Chaired by Julia Gorelik)

9:40   Andrew Shevchuk (Department of Metabolism, Digestion and Reproduction): “Scanning Ion Conductance Microscopy applications”.

9:45   George Chandramohan (Dyson School of Design Engineering): “Characterizing battery electrodes via Scanning Ion Conductance Microscopy”.

9:50   Alex Ivanov (Department of Chemistry): “Nano-tweezers for single cell biopsy ”

9:55   Joshua Edel (Department of Chemistry): “Single molecule diagnostics”

10:00 Q&A

10:10-10:40 Cellular models and molecular imaging

(Chaired by Graeme Birdsey)

10:10   Beata Wojciak-Stothard (NHLI): “Organ-on-a-chip models of pulmonary blood vessels (flow modelling/flow sensing)”.

10:15   Cesare Terracciano (NHLI): “Physiological control of mechanical load in vitro: living myocardial slices and micro-vascularised human engineered cardiac tissue”.

10:20   Marina Kuimova (Department of Chemistry): “Mapping microscopic viscosity and temperature using molecular rotors”.

10:25   Paul Edison (Department of Brain Sciences): “Molecular imaging using Positron Emission Tomography”.

10:30   Q&A

10:40-11:10 Mechanobiology: new techniques applications

(Chaired by Pamela Swiatlowska)

10:40  Fabiana Martino (NHLI): “m6A RNA modification as a mediator of heart mechanical response”. 

10:45  Darryl Overby (Department of Bioengineering): “Mechanical regulation of endothelial permeability and techniques we developed to visualise sites of permeability”.

10:50  Graeme Birdsey (NHLI): “Biomimetic Tuneable Click-Gelatin Hydrogels for Three-Dimensional Mechanoresponsive Modelling of Lymphangiogenesis”.

10:55  Vania Braga (NHLI): “Modulation of intrinsic cell rheology impacts on cell adhesion, shape and coordination with neighbours-using Young module measurements with mechano-Scanning Ion Conductance Microscopy”.

11:00  Q&A

11:10-11:40 Coffee Break

11:40-12:10 Micro- and nanoscale studies

(Chaired by Andrew Shevchuk)

11:40  Jorge Bernardino de la Serna (NHLI): “Resolving spatially and temporally how plasma membrane senses and remodels in living cells”.

11:45  Terry Tetley (NHLI): “Application of polystyrene particles in the inflammatory disease studies”.

11:50  Jake Samuel (Department of Chemistry): “Biomicrofluidic models of the gut”.

11:55  Alexandra Judina (NHLI): “Cytocypher and FRET high-throughput techniques”.

12:00  Q&A

12:10-12:40 From MRI to protein imaging

(Chaired by Yuri Korchev)

12:10  Lan Zhao (NHLI): “General introduction of Biological Imaging Centre (BIC)”.

12:15  Nicoleta Baxan (NHLI): “The role of cardiac MRI in preclinical studies”

12:20  Leitinger Birgit (NHLI): “Understanding the molecular details of discoidin domain receptor activation via lateral clustering”.

12:25   Yu Ye (Department of Brain Sciences): “A biological talk on imaging protein condensates in cells”.

12:30  Q&A

12:40-13:10 Mechanical response and fibrosis development

(Chaired by Jose L Sanchez-Alonso)

12:40  Bin Liu (NHLI):  “Molecular basis of A-Kinase anchoring protein 13 (AKAP13) dysregulation in idiopathic pulmonary fibrosis”.

12:45  Periklis Pantazis (Department of Bioengineering): “GenEPi, fluorescent sensor that reports the function of the mechanosensitive channel Piezo1 with high precision across scales”. 

12:50  Ben Goult (University of Kent): “Mechanical memory – how persistent changes in protein conformation can lead to robust, dynamically-regulated signalling outputs”.

12:55  Liming Ying (NHLI): “Can cellular mechanosensing and functional microscopy (CMFM) elucidate the functional role of CPEB3 aggregation in long-term memory”.

13:00  Q&A

13:10-13:30 Final remarks