Coronavirus

SARS-CoV-2

In 2020, the Barclay lab responded to the pandemic by pivoting from influenza to study the novel coronavirus, SARS-CoV-2.  Our research on SARS-CoV-2 includes basic virology, serology, immunology and environmental sampling.  This is a brief list of the lab's coronavirus papers and media appearances.  The lab has been part of the REACT study.  We tested if swimming pool water inactivates SARS-CoV-2.  We're sending out variants as part of the G2P consortium. 

In 2023 G2P2 consortium was funded, following from G2P. This is to be led by Wendy Barclay, to keep pace with SARS-CoV-2 variants. 

Research/Papers

Omicron breakthrough infections in vaccinated or previously infected hamsters
Jie Zhou, Ksenia Sukhova, Thomas P. Peacock, Paul F. McKay, Jonathan C. Brown, Rebecca Frise, Laury Baillon, Maya Moshe, Ruthiran Kugathasan, Robin J. Shattock, and Wendy S. Barclay
PNAS

Deep mutagenesis scanning using whole trimeric SARS-CoV-2 spike highlights the importance of NTD-RBD interactions in determining spike phenotype
Ruthiran Kugathasan, Ksenia Sukhova, Maya Moshe, Paul Kellam, and Wendy S. Barclay
PLOS PATHOGENS

Viral emissions into the air and environment after SARS-CoV-2 human challenge: a phase 1, open label, first-in-human study
Jie Zhou*, Anika Singanayagam*, Niluka Goonawardane, Maya Moshe, Fiachra P Sweeney, Ksenia Sukhova, Ben Killingley, Mariya Kalinova, Alex J Mann, Andrew P Catchpole, Michael R Barer, Neil M Ferguson, Christopher Chiu, Wendy S Barclay    
The Lancet Microbe

A self-amplifying RNA vaccine protects against SARS-CoV-2 (D614G) and Alpha variant of concern (B.1.1.7) in a transmission-challenge hamster model
Rebecca Frise, Laury Baillon, Jie Zhou, Ruthiran Kugathasan, Thomas P. Peacock, Jonathan C. Brown, Karnyart Samnuan, Paul F. McKay, Robin J. Shattock, and Wendy S. Barclay
Vaccine

Increased transmission of SARS-CoV-2 lineage B.1.1.7 (VOC 2020212/01) is not accounted for by a replicative advantage in primary airway cells or antibody escape
Jonathan C Brown*, Daniel H Goldhill*, Jie Zhou*, Thomas P Peacock, Rebecca Frise, Niluka Goonawardane, Laury Baillon, Ruthiran Kugathasan, Andreia Pinto, Paul F McKay, Jack Hassard, Maya Moshe, Aran Singanayagam, Thomas Burgoyne, Wendy S Barclay, ATACCC Investigators, PHE Virology Consortium - *Co-first author
bioRxiv

The furin cleavage site of SARS-CoV-2 spike protein is a key determinant for transmission due to enhanced replication in airway cells
Thomas P Peacock*, Daniel H Goldhill*, Jie Zhou*, Laury Baillon*, Rebecca Frise*, Olivia C Swann, Ruthiran Kugathasan, Rebecca Penn, Jonathan C Brown, Raul Y Sanchez-David, Luca Braga, Maia Kavanagh Williamson, Jack A Hassard, Ecco Staller, Brian Hanley, Michael Osborn, Mauro Giacca, Andrew D Davidson, David A Matthews, Wendy S Barclay - *Co-first author
Nature Microbiology

Clinical and laboratory evaluation of SARS-CoV-2 lateral flow assays for use in a national COVID-19 seroprevalence survey
Barnaby Flower, Jonathan C Brown, Bryony Simmons, Maya Moshe, Rebecca Frise, Rebecca Penn, Ruthiran Kugathasan, Claire Petersen, Anna Daunt, Deborah Ashby, Steven Riley, Christina Joanne Atchison, Graham P Taylor, Sutha Satkunarajah, Lenny Naar, Robert Klaber, Anjna Badhan, Carolina Rosadas, Maryam Khan, Natalia Fernandez, Macià Sureda-Vives, Hannah M Cheeseman, Jessica O'Hara, Gianluca Fontana, Scott J C Pallett, Michael Rayment, Rachael Jones, Luke S P Moore, Myra O McClure, Peter Cherepanov, Richard Tedder, Hutan Ashrafian, Robin Shattock, Helen Ward, Ara Darzi, Paul Elliot, Wendy S Barclay, Graham S Cooke
Thorax

Investigating SARS-CoV-2 surface and air contamination in an acute healthcare setting during the peak of the COVID-19 pandemic in London
Jie Zhou, Jonathan A Otter, James R Price, Cristina Cimpeanu, Danel Meno Garcia, James Kinross, Piers R Boshier, Sam Mason, Frances Bolt, Alison H Holmes & Wendy S. Barclay
Clinical Infectious Diseases

Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice
Paul F. McKay, Kai Hu, Anna K. Blakney, Karnyart Samnuan, Jonathan C. Brown, Rebecca Penn, Jie Zhou, Clément R. Bouton, Paul Rogers, Krunal Polra, Paulo J. C. Lin, Christopher Barbosa, Ying K. Tam, Wendy S. Barclay & Robin J. Shattock
Nature Communications

ACE2: The Only Thing That Matters?
Raul Y. Sanchez-David, Olivia C. Swann, Thomas P. Peacock & Wendy S. Barclay
American Journal of Respiratory and Critical Care Medicine

The Dynamics of Humoral Immune Responses Following SARS-CoV-2 Infection and the Potential for Reinfection
Paul Kellam and Wendy Barclay
Journal of General Virology

Media Appearances

Novemeber 2020
Jie tested samples from TfL to show that SARS-CoV-2 is not found on surfaces on the tube or buses.  BBC

May 2020
Serology team getting some hard-earned recognition from the BBC.  Read the article here.
Wendy was featured in the BBC Horizon - Coronavirus Special.
The lab was featured on the 6 o'clock news.

March 2020
Rebecca and Wendy are featured as taking part in Imperial's COVID-19 response for International Women's Day.  Read about them here.
Wendy is quoted in the New Scientist on why children get less ill from the coronavirus.

February 2020
As the SARS-CoV-2 outbreak continues apace, Wendy updates on what we know about the novel Coronavirus for the BMJ.  Watch here.

January 2020
Wendy discussing the current state of play with the novel coronavirus on Health Check on the BBC World Service. Listen here.