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Selected Publications

Selected Publications are listed below. View a full list of publications on Robert Enders's personal web page.

Selected publications
	Clausznitzer D, Oleksiuk O, Lovdok L, Sourjik V, Endres RG (2010) Chemotactic response and adaptation dynamics in Escherichia coli. PLoS Comput Biol 6: e1000784. Based on analyses of adaptation time courses from in vivo FRET, the paper provides a dynamic model of adaptation, and quantifies the imprecision of adaptation.
	Aquino G, Endres RG (2010) Increased accuracy of ligand sensing by receptor internalization. Phys Rev E81: 021909. The paper shows that receptor endocytosis increases the accuracy of sensing using a generalization of the Fluctuation-Dissipation Theorem to out-of-equilibrium thermodynamics.
	Endres RG, Wingreen NS (2009) Maximum likelihood and the single receptor. Phys Rev Lett103: 158101. This paper provides a lower fundamental physical limit of sensing by a single receptor than the originally Berg & Purcell limit.
	Gurry T, Kahramanoğullari O, Endres RG (2009) Biophysical mechanism for Ras-nanocluster formation and signaling in plasma membrane. PLoS One 4: e6148. The paper provides an explanation of clustering of the small GTPase Ras, as previously imaged by immunogold labeling.
	Endres RG, Wingreen NS (2009) Accuracy of direct gradient sensing by cell-surface receptors.Prog Biophys Mol Biol100: 33-39. The paper calculates the fundametal physical limit of gradient sensing based on receptor occupancy using the Fluctuation-Dissipation Theorem.
	Endres RG (2009) Polar chemoreceptor clustering by coupled trimers of dimers. Biophys J 96: 453 - 463. The paper provides a biophysical mechanism for polar receptor clustering in bacteria based on the intrinsic curvature of trimers of dimers, receptor-receptor coupling, and the increased membrane curvature at the cell poles.
	Endres RG, Wingreen NS (2008) Accuracy of direct gradient sensing by single cells. Proc Natl Acad Sci USA 105: 15749 - 15754. The paper provides an exact analytical derivation of the fundamental physical limits of gradient sensing. We find that a cell absorbing ligand molecules senses chemicals most accurately since ligand molecules are never measured more than once.
	Endres RG, Oleksiuk O, Hansen CH, Meir Y, Sourjik V, Wingreen NS (2008) Variable sizes of Escherichia coli chemoreceptor signaling teams. Mol Syst Biol 4: 211. Combining in vivo FRET experiments of chemotactic signaling with a model of receptor complexes, we find that receptor complex size increases with receptor methylation during adaptation. This indicates a new level of adaptation possibly to adjust signaling to ligand noise.
	Endres RG, Wingreen NS (2006) Precise adaptation in bacterial chemotaxis through "assistance neighborhoods". Proc Natl Acad Sci USA 103: 13040 - 13044. The paper provides an explanation for experimental observation that enzymes modify groups of receptors during adaptation. We find that this suppresses noise and leads to precise adaptation.
	Keymer JE, Endres RG, Skoge M, Meir Y, Wingreen NS (2006) Chemosensing in Escherichia coli: two regimes of two-state receptors. Proc Natl Acad Sci USA 103: 1786 - 1791. The paper provides a quantitative model of in vivo FRET data of chemotaxis signalling, and explains observed high sensitivity and cooperativity, as well as signal integration by multiple receptor types.

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