Tissue engineering is an interdisciplinary field at the intersection of engineering, and biology and medicine. It requires the considerable input from biological scientists, who provide the insight to the various developmental control mechanisms of the cell and are able to manipulate the cell at a genetic level, and the contribution of material scientists who develop the structural scaffolds.
BSEL is seeking to provide integrated solutions to tissue engineering problems working close with material scientists (Dr. Bismarck) and modellers (Drs. Xu and Stepanek) to develop suitable scaffolds and culture systems for a variety of applications ranging from bone marrow, bone, cartilage, pneumocytes (Dr. Bishop), and cardiomyocytes (Prof. Polak), as well as developing ex vivo models for disease states, such as leukaemia.
Current projects
- Development and modelling of a 3-D perfused bone marrow culture system
- Development of an ex-vivo three-dimensional model of human acute myeloid leukaemia (AML)
- Oxygen transport simulation in the human bone marrow microcirculation
- Fluid dynamics in microgravity bioreactors
- Modification of Surface Properties of Scaffolds Using Plasma Treatment for the 3-D Culture of Cord Blood Cells
- Rational Design of Surface Through the Quantification of Adhesion: Controlling Cellular Behaviour for Tissue Engineering Applications
Contact details
Professor Sakis Mantalaris
Head of BSEL Group
Chemical Engineering Department
Tel: +44 (0)20 7594 5601
Email:
a.mantalaris@imperial.ac.uk