The ICB CDT 2021 cohort of students
The students and their projects that have formed our third cohort of the CDT in Chemical Biology: Innovation in Life Sciences, who started in October 2021, are listed below.

 

Our 2021 Student Profiles

2021 student projects

Siân Allerton

Project Title: Structural and pathological consequences of aSyn/lipid membrane interactions

Siân completed her MSci in Chemistry at Durham University and in her final year she completed an external masters project as part of the Koksch Group at the Freie Universität Berlin. There she focussed on the use of synthetic peptides as effective cell culture platforms. Now she is as a member of the Aprile, Kuimova, Edel and Ivanov Group and is looking at the use of fluorescence molecules, known as molecular rotors, in the in vitro detection of the formation of toxic oligomeric aggregates of alpha-synuclein, the protein associated with Parkinson’s Disease.

ICB CDT: Meet our students - Siân Allerton

Siân Allerton

ICB CDT: Meet our students

Project Title: Structural and pathological consequences of aSyn/lipid membrane interactions

Siân completed her MSci in Chemistry at Durham University and in her final year she completed an external masters project as part of the Koksch Group at the Freie Universität Berlin. There she focussed on the use of synthetic peptides as effective cell culture platforms. Now she is as a member of the Aprile, Kuimova, Edel and Ivanov Group and is looking at the use of fluorescence molecules, known as molecular rotors, in the in vitro detection of the formation of toxic oligomeric aggregates of alpha-synuclein, the protein associated with Parkinson’s Disease.

ICB CDT: Meet our students - Sarah Chapman

Sarah Chapman

ICB CDT: Meet our students

Project Title: Electrons, leaves and light: investigating surface photodegradation of agrochemicals

1st year Ph.D. student, co-funded by EPSRC and Syngenta; supervised by Maxie Roessler & Laura Barter (Imperial College London) and Ben Robinson & Claire Donaldson (Syngenta).

Sarah completed her chemistry undergraduate at the University of Manchester. In her final year she simulated DEER spectra of multi-spin [3]- and [4]- rotaxanes to predict their structures in frozen solution (supervised by Prof. E. McInnes and Dr A. Bowen). Over the course of her Ph.D., she is investigating the photodegradation of agrochemicals on model plant leaf surfaces using EPR spectroscopy. The aim of the project is for these techniques to later be used as a tool to help scientists to better understand how agrochemicals photodegrade. In her spare time, she likes to play trumpet and piano, and reads novels (when time permits)!

ICB CDT: Meet our students - Amalia Chrysostomou

Amalia Chrysostomou

ICB CDT: Meet our students

Project Title: Biomimetic control of ovarian follicle development: combining multi-scale soft biomaterials with biochemical interactions

Amalia is a PhD candidate with the Institute of Chemical Biology. Prior to this, she completed a BSc in Mechanical Engineering and Manufacturing at the University of Cyprus and a MSc in Biomedical Engineering with a focus in biomaterials at Imperial College. In her project now, she aims to use previous knowledge acquired in her lab about the mechanical microenvironment of the ovary to develop a 3D culture environment for ovarian follicles under the supervision of Dr. Iain dunlop, Prof. Kate Hardy and Prof. Stephen Franks.

ICB CDT: Meet our students - Thomas Maher

Thomas Maher

ICB CDT: Meet our students

Project Title: Development of novel photochemical probes to investigate quadruplex DNA interactome in livings cells

Thomas received his BA and MSci. in Natural Sciences from the University of Cambridge in 2020, completing his Master’s thesis under the supervision of Prof. Oren Scherman on developing cucurbit[8]uril-mediated supramolecular hydrogels as biomimetic extracellular matrices. Following his MSci., Thomas joined the groups of Dr. Stephan Hacker and Prof. Stephan Sieber at the Technische Universität München as a research assistant. There his research focused on using a chemoproteomic platform to investigate lysine-directed covalent inhibitors (Hacker) and identifying novel antibiotic targets for pyridoxal phosphate dependent enzymes (Sieber). In 2021, Thomas joined the ICB CDT PhD programme developing novel photochemical probes to investigate the quadruplex DNA interactome in live cells.

ICB CDT: Meet our students - Xiaotong (Erin) Lin

Xiaotong (Erin) Lin

ICB CDT: Meet our students

Project Title: Investigating neurodegenerative protein aggregation by ultra-sensitive antibody detection

Xiaotong (Erin) obtained a first-class BSc in Chemistry at King’s College London before she further explored her interest in Chemical biology and completed her MRes in Chemical biology and Bio-entrepreneurship at Imperial College London. She is currently a PhD candidate with the ICB CDT; her current project focuses on probing misfolding proteins such as Amyloid-β peptide in Alzheimer's disease, co-supervised by Dr Francesco Aprile and Professor Ramon Vilar

ICB CDT: Meet our students - Abdul Zafar

Abdul Zafar

ICB CDT: Meet our students

Project Title: Caught in the act: precision tools to unravel and diagnose glycoprotein misfolding

Abdul completed his MSci in Chemistry at Imperial College London, during which he undertook a Masters project in glycobiology with Ben Schumann to probe the substrate specificities of glycosyltransferases. He then enrolled onto the ICB CDT 1+3 MRes and PhD training programme, continuing in the Schumann lab and co-supervised by David Hewings (Vertex Pharmaceuticals). In his current research, he aims to shed light on the process of protein maturation using precision chemical tools to probe glycosylation in the secretory pathway. 

Date last reviewed: 29 January 2024

Date last updated: 29 January 2024

Contact us

Project Manager:
Emma Pallett


Director: 
Dr Laura Barter

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