Photoswitches and photochemistry

Leveraging our discovery of novel heteroaromatic azo photoswitches, we continue to explore their related applications. Beyond our developing work on photopharmacology, we have published on the use of our molecules as photoswitchable bases, in photoswitchable surfactants and within molecular cages.  Representative publications: ChemRxiv 2023. DOI; JACS Au 2022, 2, 2670. DOI; Chem. Commun. 2016,  52, 4521. DOI.

One area of recent interest has been in molecular solar thermal (MOST) energy storage materials. These photoswitchable materials convert photon energy to thermal energy by reversible isomerisation and energy storage in a metastable isomeric state. Such materials have high potential in applications ranging from waste heat recycling in vehicles and ‘off-grid’ homes, to heated clothing and other cold-climate amenities. We have been studying the arylazopyrazoles and azobispyrazoles in this regard, with several exciting outcomes. These include: (1) the discovery of a material that can store up to 92 kJ/mol of thermal energy for extended timescales (>2 weeks) while allowing for energy release at subzero temperatures, (2) the discovery of a material where energy release can occur electrocatalytically in the condensed phase, and (3) the discovery of materials with unprecedentedly large effective light penetration depths (1400 μm of UV at 365 nm and 1400 μm of visible light at 530 nm). Representative publications: J. Am. Chem. Soc. 2022, 144, 19430. DOI; J. Am. Chem. Soc. 2021, 143, 15250. DOI; J. Am. Chem. Soc. 2020, 142, 8688. DOI.

Circularly polarised light (CPL) is a form of chiral electromagnetic radiation, which theoretically should be able to induce absolute asymmetric synthesis via photochemical reactions. Indeed, the interaction of CPL with primordial interstellar molecules (combined with some amplification mechanism) is one hypothesis for the evolution of homochirality on Earth. As early as the 19th century van’t Hoff and Le Bel pointed out that CPL may be exploited to induce asymmetric photochemistry, however despite extensive efforts in the subsequent century, only a few examples exist with moderate levels of asymmetric induction, and no examples exist for highly enantioselective reactions. Nonetheless, CPL-mediated photochemistry continues to draw significant interest in asymmetric synthesis, origins of life science, asymmetric photoswitching of chiral molecules, molecular motors, and liquid crystalline materials.

Building on our work studying the interaction of CPL with homochiral helicenes in photo-transistors, we have revisited the asymmetric photochemical synthesis of helicenes from a prochiral precursor using CPL in collaboration with Dr Marina Kuimova. We have demonstrated that two CPL wavelengths can control separate reactions simultaneously. In doing so, a photostationary state can be established such that the enantiomeric induction intrinsic to each step can combine additively, significantly increasing the asymmetric induction possible in these reactions. We continue to explore other mechanisms to enhance CPL photochemistry. Representative publication: Chem. Sci. 2015, 6, 3853. DOI.