Resistance to host defences
During infection, bacteria face the twin threats of antibiotics and the host immune system. Resistance to one sometimes confers resistance to the other.
Researchers in this field include:
- Dr Luke Allsopp: Bacterial secretion systems and biofilms factors
- Professor Darius Armstrong-James: Basis of fungal persistence and adaptation in the host, phenotypic microarray facility
- Dr Thomas Clarke: Microbiota influence on host responses to bacterial infection and vaccination
- Dr Abigail Clements: The role of bacterial surface structures in pathogenesis
- Professor Marc Dionne: How do host defences promote acquisition of antimicrobial resistance?
- Dr Andy Edwards: Bacterial DNA repair systems
- Dr Ana Eulalio: Role of microRNAs and the impact of bacterial intracellular lifestyles on pathogenesis
- Dr Harry Low: Membrane remodelling processes to evade the immune system and develop resistance
- Dr Alex McCarthy: Pathogens exploitation of immunomodulatory receptors
- Dr Brian Robertson: Host pathogen-interactions underlying tuberculosis infection
- Dr Avinash Shenoy: Inflammasome evasion by enteric bacterial pathogens
- Dr Matthew Siggins: Bacterial virulence factors in invasion
- Dr Teresa Thurston: Pathogen inhibition of innate immune signaling