Cleo Kontoravdi

Cleo Kontoravdi's interests lie in the area of biotechnology, with particular focus on the application of systems engineering principles to bioprocessing.

My research involves the systematic integration of model-based tools, such as sensitivity analysis, design of experiments and optimisation, with experimentation on mammalian cell culture systems. Topics of interest include optimisation of process conditions, controlling protein glycosylation, metabolic flux analysis and multiscale modelling.

I obtained my MEng and PhD in Chemical Engineering from Imperial College London. I then worked as a Research and Development Scientist at Lonza Biologics (Slough, U.K.) before rejoining Imperial as a Lonza/RCUK Fellow in Biopharmaceuticals Processing. I am currently a Senior Lecturer at the Department of Chemical Engineering.

Links to main publications

• Fan Y, Del Val IJ, Mueller C, Sen JW, Rasmussen SK, Kontoravdi C, Weilguny D, Andersen MRet al., 2015, Amino Acid and Glucose Metabolism in Fed-Batch CHO Cell Culture Affects Antibody Production and Glycosylation, BIOTECHNOLOGY AND BIOENGINEERING, Vol: 112, Pages: 521-535
• Sou SN, Sellick C, Lee K, Mason A, Kyriakopoulos S, Polizzi KM, Kontoravdi C, 2015, How does mild hypothermia affect monoclonal antibody glycosylation?, Biotechnology and Bioengineering, Vol: 112, Pages: 1165-1176
• Jedrzejewski PM, del Val IJ, Constantinou A, Dell A, Haslam SM, Polizzi KM, Kontoravdi C, 2014, Towards Controlling the Glycoform: A Model Framework Linking Extracellular Metabolites to Antibody Glycosylation, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol: 15, Pages: 4492-4522
• Kyriakopoulos S, Kontoravdi C, 2014, A Framework for the Systematic Design of Fed-Batch Strategies in Mammalian Cell Culture, BIOTECHNOLOGY AND BIOENGINEERING, Vol: 111, Pages: 2466-2476
• del Val IJ, Nagy JM, Kontoravdi C, 2011, A dynamic mathematical model for monoclonal antibody N-linked glycosylation and nucleotide sugar donor transport within a maturing Golgi apparatus, BIOTECHNOLOGY PROGRESS, Vol: 27, Pages: 1730-1743