Publications
Notable Recent Publications
These are some recent publications which give a flavour of the research from the Barclay lab. For a complete list of publications, please see below.
Species difference in ANP32A underlies influenza A virus polymerase host restriction. Nature (2016).
Jason S. Long, Efstathios S. Giotis, Olivier Moncorgé, Rebecca Frise, Bhakti Mistry, Joe James, Mireille Morisson, Munir Iqbal, Alain Vignal, Michael A. Skinner & Wendy S. Barclay
This paper identified a key factor that explained why the polymerases from avian influenza viruses are restricted in humans. For more, please see the associated New and Views.
See our latest ANP32 papers here: eLIFE, Journal of Virology, Journal of Virology.
The mechanism of resistance to favipiravir in influenza. PNAS (2018).
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Internal genes of a highly pathogenic H5N1 influenza virus determine high viral replication in myeloid cells and severe outcome of infection in mice. Plos Path. (2018).
Hui Li*, Konrad C. Bradley*, Jason S. Long, Rebecca Frise, Jonathan W. Ashcroft, Lorian C. Hartgroves, Holly Shelton, Spyridon Makris, Cecilia Johansson, Bin Cao & Wendy S. Barclay
Why do avian influenza viruses like H5N1 cause such severe disease in humans? This paper demonstrated that H5N1 viruses replicate better than human viruses in myeloid cells from mice leading to a cytokine storm and more severe disease.
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Journal articleElderfield R, Barclay W, 2011,
Influenza Pandemics
, HOT TOPICS IN INFECTION AND IMMUNITY IN CHILDREN VIII, Vol: 719, Pages: 81-103, ISSN: 0065-2598- Author Web Link
- Cite
- Citations: 14
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Journal articleMoncorge O, Mura M, Barclay WS, 2010,
Evidence for Avian and Human Host Cell Factors That Affect the Activity of Influenza Virus Polymerase
, JOURNAL OF VIROLOGY, Vol: 84, Pages: 9978-9986, ISSN: 0022-538X- Author Web Link
- Cite
- Citations: 79
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Journal articleHartgroves LCS, Koudstaal W, McLeod C, et al., 2010,
Rapid generation of a well-matched vaccine seed from a modern influenza A virus primary isolate without recourse to eggs
, VACCINE, Vol: 28, Pages: 2973-2979, ISSN: 0264-410X- Author Web Link
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- Citations: 8
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Journal articleRehwinkel J, Tan CP, Goubau D, et al., 2010,
RIG-I detects viral genomic RNA during negative-strand RNA virus infection.
, Cell, Vol: 140, Pages: 397-408RIG-I is a key mediator of antiviral immunity, able to couple detection of infection by RNA viruses to the induction of interferons. Natural RIG-I stimulatory RNAs have variously been proposed to correspond to virus genomes, virus replication intermediates, viral transcripts, or self-RNA cleaved by RNase L. However, the relative contribution of each of these RNA species to RIG-I activation and interferon induction in virus-infected cells is not known. Here, we use three approaches to identify physiological RIG-I agonists in cells infected with influenza A virus or Sendai virus. We show that RIG-I agonists are exclusively generated by the process of virus replication and correspond to full-length virus genomes. Therefore, nongenomic viral transcripts, short replication intermediates, and cleaved self-RNA do not contribute substantially to interferon induction in cells infected with these negative strand RNA viruses. Rather, single-stranded RNA viral genomes bearing 5'-triphosphates constitute the natural RIG-I agonists that trigger cell-intrinsic innate immune responses during infection.
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Journal articleAyora-Talavera G, Shelton H, Scull MA, et al., 2009,
Mutations in H5N1 Influenza Virus Hemagglutinin that Confer Binding to Human Tracheal Airway Epithelium
, PLOS ONE, Vol: 4, ISSN: 1932-6203- Author Web Link
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- Citations: 52
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Journal articleTsang J, Chain BM, Miller RF, et al., 2009,
HIV-1 infection of macrophages is dependent on evasion of innate immune cellular activation
, AIDS, Vol: 23, Pages: 2255-2263, ISSN: 0269-9370- Author Web Link
- Cite
- Citations: 68
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Journal articleJohnson BF, Wilson LE, Ellis J, et al., 2009,
Fatal Cases of Influenza A in Childhood
, PLOS ONE, Vol: 4, ISSN: 1932-6203- Author Web Link
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- Citations: 20
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Journal articleWise HM, Foeglein A, Sun J, et al., 2009,
A Complicated Message: Identification of a Novel PB1-Related Protein Translated from Influenza A Virus Segment 2 mRNA
, JOURNAL OF VIROLOGY, Vol: 83, Pages: 8021-8031, ISSN: 0022-538X- Author Web Link
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- Citations: 284
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Journal articleScull MA, Gillim-Ross L, Santos C, et al., 2009,
Avian Influenza Virus Glycoproteins Restrict Virus Replication and Spread through Human Airway Epithelium at Temperatures of the Proximal Airways
, PLOS PATHOGENS, Vol: 5, ISSN: 1553-7366- Author Web Link
- Cite
- Citations: 60
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Journal articleKoudstaal W, Hartgroves L, Havenga M, et al., 2009,
Suitability of PER.C6® cells to generate epidemic and pandemic influenza vaccine strains by reverse genetics
, VACCINE, Vol: 27, Pages: 2588-2593, ISSN: 0264-410X- Author Web Link
- Cite
- Citations: 22
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