In this section
@article{Zhu:2024:10.1021/jacs.4c00845,
author = {Zhu, KK and Contamina, IG and Ces, O and Barter, LMC and Hindley, JW and Elani, Y},
doi = {10.1021/jacs.4c00845},
journal = {Journal of the American Chemical Society},
pages = {13176--13182},
title = {Magnetic modulation of biochemical synthesis in synthetic cells},
url = {http://dx.doi.org/10.1021/jacs.4c00845},
volume = {146},
year = {2024}
}
TY - JOUR
AB - Synthetic cells can be constructed from diverse molecular components, without the design constraints associated with modifying 'living' biological systems. This can be exploited to generate cells with abiotic components, creating functionalities absent in biology. One example is magnetic responsiveness, the activation and modulation of encapsulated biochemical processes using a magnetic field, which is absent from existing synthetic cell designs. This is a critical oversight, as magnetic fields are uniquely bio-orthogonal, noninvasive, and highly penetrative. Here, we address this by producing artificial magneto-responsive organelles by coupling thermoresponsive membranes with hyperthermic Fe3O4 nanoparticles and embedding them in synthetic cells. Combining these systems enables synthetic cell microreactors to be built using a nested vesicle architecture, which can respond to alternating magnetic fields through in situ enzymatic catalysis. We also demonstrate the modulation of biochemical reactions by using different magnetic field strengths and the potential to tune the system using different lipid compositions. This platform could unlock a wide range of applications for synthetic cells as programmable micromachines in biomedicine and biotechnology.
AU - Zhu,KK
AU - Contamina,IG
AU - Ces,O
AU - Barter,LMC
AU - Hindley,JW
AU - Elani,Y
DO - 10.1021/jacs.4c00845
EP - 13182
PY - 2024///
SN - 0002-7863
SP - 13176
TI - Magnetic modulation of biochemical synthesis in synthetic cells
T2 - Journal of the American Chemical Society
UR - http://dx.doi.org/10.1021/jacs.4c00845
UR - https://pubs.acs.org/doi/10.1021/jacs.4c00845
UR - http://hdl.handle.net/10044/1/114020
VL - 146
ER -
+44 (0)20 7594 1885
l.barter@imperial.ac.uk
301N
Molecular Sciences Research Hub
White City Campus