Learning from resilience

Theme 3: Endothelial Resilience

From pathophysiology to a translational treatment target in CVD 

Endothelial resilience refers to the remarkable ability of endothelial cells, which line the interior surface of blood vessels, to maintain functionality and adapt to various physiological challenges and stressors. These resilient cells play a pivotal role in regulating vascular tone, permeability, and inflammatory responses, thereby influencing overall cardiovascular health. Through intricate mechanisms endothelial cells exhibit resilience against factors such as oxidative stress, inflammation, and other noxious influences that harm the cardiovascular system. Our theme will aim to explore restoring as well as enhancing endothelial resilience, which is increasingly recognised as a key therapeutic target in preventing and managing cardiovascular diseases. Our work underscores the importance of maintaining endothelial health as a vital part of maintaining overall cardiovascular homeostasis and longevity.