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@article{Rapeaux:2022,
author = {Rapeaux, A and Constandinou, T},
journal = {Frontiers in Neuroscience},
title = {HFAC dose repetition and accumulation leads to progressively longer block carryover effect in rat sciatic nerve},
url = {https://www.frontiersin.org/articles/10.3389/fnins.2022.852166/full},
volume = {16},
year = {2022}
}

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TY - JOUR
AB - This paper describes high-frequency nerve block experiments carried out on rat sciatic nerves to measure the speed of recoveryof A fibres from block carryover. Block carryover is the process by which nerve excitability remains suppressed temporarily afterHigh Frequency Alternative (HFAC) block is turned off following its application. In this series of experiments 5 rat sciatic nerveswere extracted and prepared for ex-vivo stimulation and recording in a specially designed perfusion chamber. For each nerverepeated HFAC block and concurrent stimulation trials were carried out to observe block carryover after signal shutoff. The nervewas allowed to recover fully between each trial. Time to recovery from block was measured by monitoring for when relativenerve activity returned to within 90% of baseline levels measured at the start of each trial. HFAC block carryover duration wasfound to be dependent on accumulated dose by statistical test for two different HFAC durations. The carryover property of HFACblock on A fibres could enable selective stimulation of autonomic nerve fibres such as C fibres for the duration of carryover. Blockcarryover is particularly relevant to potential chronic clinical applications of block as it reduces power requirements forstimulation to provide the blocking effect. This work characterises this process towards the creation of a model describing itsbehaviour.
AU - Rapeaux,A
AU - Constandinou,T
PY - 2022///
SN - 1662-453X
TI - HFAC dose repetition and accumulation leads to progressively longer block carryover effect in rat sciatic nerve
T2 - Frontiers in Neuroscience
UR - https://www.frontiersin.org/articles/10.3389/fnins.2022.852166/full
UR - http://hdl.handle.net/10044/1/97057
VL - 16
ER -

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