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@article{Miao:2024:10.1038/s41593-024-01638-y,
author = {Miao, A and Luo, T and Hsieh, B and Edge, CJ and Gridley, M and Wong, R and Constandinou, T and Wisden, W and Franks, N},
doi = {10.1038/s41593-024-01638-y},
journal = {Nature Neuroscience},
pages = {1046--1050},
title = {Brain clearance is reduced during sleep and anesthesia},
url = {http://dx.doi.org/10.1038/s41593-024-01638-y},
volume = {27},
year = {2024}
}

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TY  - JOUR
AB  - It has been suggested that the function of sleep is to actively clear metabolites and toxins from the brain. Enhanced clearance is also said to occur during anesthesia. Here, we measure clearance and movement of fluorescent molecules in the brains of male mice and show that movement is, in fact, independent of sleep and wake or anesthesia. Moreover, we show that brain clearance is markedly reduced, not increased, during sleep and anesthesia.
AU  - Miao,A
AU  - Luo,T
AU  - Hsieh,B
AU  - Edge,CJ
AU  - Gridley,M
AU  - Wong,R
AU  - Constandinou,T
AU  - Wisden,W
AU  - Franks,N
DO  - 10.1038/s41593-024-01638-y
EP  - 1050
PY  - 2024///
SN  - 1097-6256
SP  - 1046
TI  - Brain clearance is reduced during sleep and anesthesia
T2  - Nature Neuroscience
UR  - http://dx.doi.org/10.1038/s41593-024-01638-y
UR  - https://www.nature.com/articles/s41593-024-01638-y
UR  - http://hdl.handle.net/10044/1/110528
VL  - 27
ER  -

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