@article{Oliver:2009:10.1177/193229680900300623,
author = {Oliver, N and Georgiou, P and Johnston, D and Toumazou, C},
doi = {10.1177/193229680900300623},
journal = {J Diabetes Sci Technol},
pages = {1419--1424},
title = {A benchtop closed-loop system controlled by a bio-inspired silicon implementation of the pancreatic beta cell.},
url = {http://dx.doi.org/10.1177/193229680900300623},
volume = {3},
year = {2009}
}

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TY  - JOUR
AB  - UNLABELLED: The normal pancreatic beta-cell membrane depolarizes in response to increasing concentrations of glucose in a bursting pattern. At <7 mM (126 mg/dl), the cell is electrically silent. The bursting pulse width increases as glucose rises >7 mM (126 mg/dl) until a continuous train of bursting is seen at >25 mM (450 mg/dl). A bio-inspired silicon device has been developed using analogue electronics to implement membrane depolarization of the beta cell. The device is ultralow powered, miniaturized (5 x 5 mm), and produces a bursting output identical to that characterized in electrophysiological studies. OBJECTIVE: The goal of this study was to demonstrate the ability of silicon implementation of beta-cell electrophysiology to respond to a simulated glucose input and to drive an infusion pump in vitro. METHOD: The silicon device response to a current source was recorded at varying simulated glucose concentrations. Subsequently, the bursting response to a changing analyte concentration measured by an amperometric enzyme electrode was converted to a voltage, driving a syringe pump loaded with a 50-ml syringe containing water. RESULTS: Bursting responses are comparable to those recorded in electrophysiology. Silicon beta-cell implementation bursts with a pulse width proportional to concentration and is able to drive an infusion pump. CONCLUSION: This is the first in vitro demonstration of closed loop insulin delivery utilizing miniaturized silicon implementation of beta-cell physiology in analogue electronics.
AU  - Oliver,N
AU  - Georgiou,P
AU  - Johnston,D
AU  - Toumazou,C
DO  - 10.1177/193229680900300623
EP  - 1424
PY  - 2009///
SP  - 1419
TI  - A benchtop closed-loop system controlled by a bio-inspired silicon implementation of the pancreatic beta cell.
T2  - J Diabetes Sci Technol
UR  - http://dx.doi.org/10.1177/193229680900300623
UR  - https://www.ncbi.nlm.nih.gov/pubmed/20144397
VL  - 3
ER  - 

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