@inproceedings{Reddy:2015:10.1177/1932296815616134,
author = {Reddy, M and Herrero, P and Sharkawy, ME and Pesl, P and Jugnee, N and Pavitt, D and Godsland, IF and Alberti, G and Toumazou, C and Johnston, DG and Georgiou, P and Oliver, NS},
doi = {10.1177/1932296815616134},
pages = {405--413},
title = {Metabolic Control With the Bio-inspired Artificial Pancreas in Adults With Type 1 Diabetes: A 24-Hour Randomized Controlled Crossover Study.},
url = {http://dx.doi.org/10.1177/1932296815616134},
year = {2015}
}

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TY  - CPAPER
AB  - BACKGROUND: The Bio-inspired Artificial Pancreas (BiAP) is a closed-loop insulin delivery system based on a mathematical model of beta-cell physiology and implemented in a microchip within a low-powered handheld device. We aimed to evaluate the safety and efficacy of the BiAP over 24 hours, followed by a substudy assessing the safety of the algorithm without and with partial meal announcement. Changes in lactate and 3-hydroxybutyrate concentrations were investigated for the first time during closed-loop. METHODS: This is a prospective randomized controlled open-label crossover study. Participants were randomly assigned to attend either a 24-hour closed-loop visit connected to the BiAP system or a 24-hour open-loop visit (standard insulin pump therapy). The primary outcome was percentage time spent in target range (3.9-10 mmol/l) measured by sensor glucose. Secondary outcomes included percentage time in hypoglycemia (<3.9 mmol/l) and hyperglycemia (>10 mmol/l). Participants were invited to attend for an additional visit to assess the BiAP without and with partial meal announcements. RESULTS: A total of 12 adults with type 1 diabetes completed the study (58% female, mean [SD] age 45 [10] years, BMI 25 [4] kg/m(2), duration of diabetes 22 [12] years and HbA1c 7.4 [0.7]% [58 (8) mmol/mol]). The median (IQR) percentage time in target did not differ between closed-loop and open-loop (71% vs 66.9%, P = .9). Closed-loop reduced time spent in hypoglycemia from 17.9% to 3.0% (P < .01), but increased time was spent in hyperglycemia (10% vs 28.9%, P = .01). The percentage time in target was higher when all meals were announced during closed-loop compared to no or partial meal announcement (65.7% [53.6-80.5] vs 45.5% [38.2-68.3], P = .12). CONCLUSIONS: The BiAP is safe and achieved equivalent time in target as measured by sensor glucose, with improvement in hypoglycemia, when compared to standard pump therapy.
AU  - Reddy,M
AU  - Herrero,P
AU  - Sharkawy,ME
AU  - Pesl,P
AU  - Jugnee,N
AU  - Pavitt,D
AU  - Godsland,IF
AU  - Alberti,G
AU  - Toumazou,C
AU  - Johnston,DG
AU  - Georgiou,P
AU  - Oliver,NS
DO  - 10.1177/1932296815616134
EP  - 413
PY  - 2015///
SP  - 405
TI  - Metabolic Control With the Bio-inspired Artificial Pancreas in Adults With Type 1 Diabetes: A 24-Hour Randomized Controlled Crossover Study.
UR  - http://dx.doi.org/10.1177/1932296815616134
UR  - https://www.ncbi.nlm.nih.gov/pubmed/26581881
ER  - 

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