In this section
@article{Wang:2024:10.1007/s10237-023-01757-8,
author = {Wang, K and Armour, CH and Gibbs, RGJ and Xu, XY},
doi = {10.1007/s10237-023-01757-8},
journal = {Biomechanics and Modeling in Mechanobiology},
pages = {61--71},
title = {A numerical study of the effect of thrombus breakdown on predicted thrombus formation and growth},
url = {http://dx.doi.org/10.1007/s10237-023-01757-8},
volume = {23},
year = {2024}
}
TY - JOUR
AB - Thrombosis is a complex biological process which involves many biochemical reactions and is influenced by blood flow. Various computational models have been developed to simulate natural thrombosis in diseases such as aortic dissection (AD), and device-induced thrombosis in blood-contacting biomedical devices. While most hemodynamics-based models consider the role of low shear stress in the initiation and growth of thrombus, they often ignore the effect of thrombus breakdown induced by elevated shear stress. In this study, a new shear stress-induced thrombus breakdown function is proposed and implemented in our previously published thrombosis model. The performance of the refined model is assessed by quantitative comparison with experimental data on thrombus formation in a backward-facing step geometry, and qualitative comparison with in vivo data obtained from an AD patient. Our results show that incorporating thrombus breakdown improves accuracy in predicted thrombus volume and captures the same pattern of thrombus evolution as measured experimentally and in vivo. In the backward-facing step geometry, thrombus breakdown impedes growth over the step and downstream, allowing a stable thrombus to be reached more quickly. Moreover, the predicted thrombus volume, height and length are in better agreement with the experimental measurements compared to the original model which does not consider thrombus breakdown. In the patient-specific AD, the refined model outperforms the original model in predicting the extent and location of thrombosis. In conclusion, the effect of thrombus breakdown is not negligible and should be included in computational models of thrombosis.
AU - Wang,K
AU - Armour,CH
AU - Gibbs,RGJ
AU - Xu,XY
DO - 10.1007/s10237-023-01757-8
EP - 71
PY - 2024///
SN - 1617-7940
SP - 61
TI - A numerical study of the effect of thrombus breakdown on predicted thrombus formation and growth
T2 - Biomechanics and Modeling in Mechanobiology
UR - http://dx.doi.org/10.1007/s10237-023-01757-8
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:001046095700001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR - http://hdl.handle.net/10044/1/106010
VL - 23
ER -
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