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• Journal article
  Sun N, Wood NB, Hughes AD, Thom SAM, Xu XYet al., 2007,

  Influence of pulsatile flow on LDL transport in the arterial wall

  , ANNALS OF BIOMEDICAL ENGINEERING, Vol: 35, Pages: 1782-1790, ISSN: 0090-6964
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  • Citations: 30
• Journal article
  Augst AD, Ariff B, Thom SAGM, Xu XY, Hughes ADet al., 2007,

  Analysis of complex flow and the relationship between blood pressure, wall shear stress, and intima-media thickness in the human carotid artery

  , AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol: 293, Pages: H1031-H1037, ISSN: 0363-6135
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  • Citations: 73
• Journal article
  Ma CYJ, Kumar R, Xu XY, Mantalaris Aet al., 2007,

  A combined fluid dynamics, mass transport and cell growth model for a three-dimensional perfused biorector for tissue engineering of haematopoietic cells

  , BIOCHEMICAL ENGINEERING JOURNAL, Vol: 35, Pages: 1-11, ISSN: 1369-703X
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  • Citations: 34
• Journal article
  Downie SP, Firmin DN, Wood NB, Thom SA, Hughes AD, Wolfe JNH, Xu XYet al., 2007,

  Role of MRI in investigating the effects of elastic compression stockings on the deformation of the superficial and deep veins in the lower leg

  , JOURNAL OF MAGNETIC RESONANCE IMAGING, Vol: 26, Pages: 80-85, ISSN: 1053-1807
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  • Citations: 20
• Journal article
  Sun N, Wood NB, Hughes AD, Thom SAM, Xu XYet al., 2007,

  Effects of transmural pressure and wall shear stress on LDL accumulation in the arterial wall: a numerical study using a multilayered model

  , AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol: 292, Pages: H3148-H3157, ISSN: 0363-6135
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  • Citations: 51
• Book chapter
  XY Xu, NB Wood, 2007,

  The proximal carotid arteries – image-based computational modelling

  , Carotid Disease: The Role of Imaging in Diagnosis and Management, Editors: Gillard, Graves, Hatsukami, Yuan, Cambridge, Publisher: Cambridge University Press, Pages: 313-323, ISBN: 9780521862264
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• Conference paper
  Torii R, Wood NB, Hadjiloizou N, Wright A, Hughes AD, Thom SAM, Xu XYet al., 2007,

  Does the difference in realistic waveform before and after stenting affect hemodynamics in stenosed coronary artery?

  , ASME Summer Bioengineering Conference, Publisher: AMER SOC MECHANICAL ENGINEERS, Pages: 467-468
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• Journal article
  Torii R, Wood NB, Hughes AD, Thom SA, Aguado-Sierra J, Davies JE, Francis DP, Parker KH, Xu XYet al., 2007,

  A computational study on the influence of catheter-delivered intravascular probes on blood flow in a coronary artery model

  , JOURNAL OF BIOMECHANICS, Vol: 40, Pages: 2501-2509, ISSN: 0021-9290
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  • Citations: 20
• Conference paper
  Sun N, Torii R, Wood NB, Wright A, Hughes AD, Thom SAM, Xu XYet al., 2007,

  Numerical simulation of blood-wall albumin transport in a realistic human right coronary artery

  , ASME Summer Bioengineering Conference, Publisher: AMER SOC MECHANICAL ENGINEERS, Pages: 107-108
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• Conference paper
  Borghi A, Wood NB, Mohiaddin RH, Xu XYet al., 2007,

  Fluid-solid interaction simulation of flow and stress pattern in thoracoabdominal aneurysms: A patient specific study

  , 6th Symposium on Fluid-Structure Interactions, Aeroelasticity and Flow-Induced Vibration and Noise, Publisher: AMER SOC MECHANICAL ENGINEERS, Pages: 671-675
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• Journal article
  Borghi A, Wood NB, Mohiaddin RH, Xu XYet al., 2006,

  3D geometric reconstruction of thoracic aortic aneurysms

  , BIOMEDICAL ENGINEERING ONLINE, Vol: 5, ISSN: 1475-925X
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  • Citations: 15
• Journal article
  Wood NB, Zhao SZ, Zambanini A, Jackson M, Gedroyc W, Thom SA, Hughes AD, Xu XYet al., 2006,

  Curvature and tortuosity of the superficial femoral artery: a possible risk factor for peripheral arterial disease

  , JOURNAL OF APPLIED PHYSIOLOGY, Vol: 101, Pages: 1412-1418, ISSN: 8750-7587
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  • Citations: 104
• Journal article
  Ariff B, Zambanini A, Vamadeva S, Barratt D, Xu Y, Sever P, Stanton A, Hughes A, Thom Set al., 2006,

  Candesartan- and atenolol-based treatments induce different patterns of carotid artery and left ventricular remodeling in hypertension

  , STROKE, Vol: 37, Pages: 2381-2384, ISSN: 0039-2499
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  • Citations: 41
• Journal article
  Sun N, Wood NB, Hughes AD, Thom SAM, Xu XYet al., 2006,

  Fluid-wall modelling of mass transfer in an axisymmetric stenosis: Effects of shear-dependent transport properties

  , ANNALS OF BIOMEDICAL ENGINEERING, Vol: 34, Pages: 1119-1128, ISSN: 0090-6964
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  • Citations: 81
• Journal article
  Leung JH, Wright AR, Cheshire N, Crane J, Thom SA, Hughes AD, Xu Yet al., 2006,

  Fluid structure interaction of patient specific abdominal aortic aneurysms: a comparison with solid stress models

  , Biomedical Engineering Online, Vol: 5, ISSN: 1475-925X

  BackgroundAbdominal aortic aneurysm (AAA) is a dilatation of the aortic wall, which can rupture, if left untreated. Previous work has shown that, maximum diameter is not a reliable determinant of AAA rupture. However, it is currently the most widely accepted indicator. Wall stress may be a better indicator and promising patient specific results from structural models using static pressure, have been published. Since flow and pressure inside AAA are non-uniform, the dynamic interaction between the pulsatile flow and wall may influence the predicted wall stress. The purpose of the present study was to compare static and dynamic wall stress analysis of patient specific AAAs.MethodPatient-specific AAA models were created from CT scans of three patients. Two simulations were performed on each lumen model, fluid structure interaction (FSI) model and static structural (SS) model. The AAA wall was created by dilating the lumen with a uniform 1.5 mm thickness, and was modeled as a non-linear hyperelastic material. Commercial finite element code Adina 8.2 was used for all simulations. The results were compared between the FSI and SS simulations.ResultsResults are presented for the wall stress patterns, wall shear stress patterns, pressure, and velocity fields within the lumen. It is demonstrated that including fluid flow can change local wall stresses slightly. However, as far as the peak wall stress is concerned, this effect is negligible as the difference between SS and FSI models is less than 1%.ConclusionThe results suggest that fully coupled FSI simulation, which requires considerable computational power to run, adds little to rupture risk prediction. This justifies the use of SS models in previous studies.

  • Abstract
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• Book chapter
  Wood N B, Xu X Y, 2006,

  Modelling of haemodynamics in the cardiovascular system by integrating medical imaging techniques and computer modelling tools.

  , Multidisciplinary Approaches to Theory in Medicine., Editors: Paton, McNamara, Paton, McNamara, Amsterdam, The Netherlands, Publisher: Elsevier B V, Pages: 325-351, ISBN: 9780444518064
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• Journal article
  Ma CYJ, Mantalaris A, Xu XY, 2005,

  Development of a mathematical model for a 3-D perfused bone marrow culture system

  , AIChE Annual Meeting, Conference Proceedings, Pages: 8808-8818

  Bone marrow (BM) is a three-dimensional tissue and the site of blood formation. The successful reconstruction of the BM has enormous potential benefits to the society. Its success depends, partly, on the development of a suitable culture system necessary for its growth. In the present work, we have developed a mathematical model for a 3-D perfused BM culture system that captures the growth characteristics of the BM microenvironment, and as a first approximation, mimics the structural entity of in vivo BM. The model has been used to investigate cellular growth, fluid flow, shear stress and nutrient distribution within a Rotating Wall Perfused Bioreactor - RWPB (Synthecon Inc.). Based on our preliminary results, for a 2 week culture, it was observed that the total cell number increased by 30 and 38 fold for a scaffold with 90% and 80% porosity, respectively. Further analysis showed that, with a 20% oxygen supply, the oxygen tension was sufficiently maintained to avoid hypoxic regions, but with increasing axial distance in the bioreactor some areas experienced low oxygen levels; though this effect varied with porosity of the scaffold.

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  • Citations: 1
• Journal article
  Leung JH, Wright A, Cheshire N, Thom SA, Hughes AD, Crane J, Xu YXet al., 2005,

  Fluid-structure interaction in patient specific models of the abdominal aortic aneurysm

  , Proceedings of the 2005 Summer Bioengineering Conference, Vol: 2005, Pages: 1450-1451
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• Journal article
  Wood NB, Exarchou I, Xu XY, Mistry P, Witt N, Thom SA, Hughes ADet al., 2005,

  Progress with the study of retinal hemodynamics in normotensive and hypertensive patients

  , Proceedings of the 2005 Summer Bioengineering Conference, Vol: 2005, Pages: 259-260
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  • Citations: 1
• Journal article
  Wood NB, Xu XY, 2005,

  18 Modelling of haemodynamics in the cardiovascular system by integrating medical imaging techniques and computer modelling tools

  , Studies in Multidisciplinarity, Vol: 3, Pages: 325-351, ISSN: 1571-0831
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  • Citations: 2

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