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@article{Aryaman:2017:10.1002/bies.201700001,
author = {Aryaman, J and hoitzing, H and burgstaller, J and johnston, I and Jones, NS},
doi = {10.1002/bies.201700001},
journal = {Bioessays},
title = {Mitochondrial heterogeneity, metabolic scaling and cell death},
url = {http://dx.doi.org/10.1002/bies.201700001},
volume = {39},
year = {2017}
}
TY - JOUR
AB - Heterogeneity in mitochondrial content has been previously suggested as a major contributor to cellular noise, with multiple studies indicating its direct involvement in biomedically important cellular phenomena. A recently published dataset explored the connection between mitochondrial functionality and cell physiology, where a non-linearity between mitochondrial functionality and cell size was found. Using mathematical models, we suggest that a combination of metabolic scaling and a simple model of cell death may account for these observations. However, our findings also suggest the existence of alternative competing hypotheses, such as a non-linearity between cell death and cell size. While we find that the proposed non-linear coupling between mitochondrial functionality and cell size provides a compelling alternative to previous attempts to link mitochondrial heterogeneity and cell physiology, we emphasise the need to account for alternative causal variables, including cell cycle, size, mitochondrial density and death, in future studies of mitochondrial physiology.
AU - Aryaman,J
AU - hoitzing,H
AU - burgstaller,J
AU - johnston,I
AU - Jones,NS
DO - 10.1002/bies.201700001
PY - 2017///
SN - 1521-1878
TI - Mitochondrial heterogeneity, metabolic scaling and cell death
T2 - Bioessays
UR - http://dx.doi.org/10.1002/bies.201700001
UR - http://hdl.handle.net/10044/1/48451
VL - 39
ER -