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@article{August:2006:10.1007/s11538-006-9132-6,
author = {August, E and Parker, KH and Barahona, M},
doi = {10.1007/s11538-006-9132-6},
journal = {BULLETIN OF MATHEMATICAL BIOLOGY},
pages = {(1233--1254)--(1233--1254)},
title = {A dynamical model of lipoprotein metabolism},
url = {http://dx.doi.org/10.1007/s11538-006-9132-6},
volume = {69},
year = {2006}
}
TY - JOUR
AB - We present a dynamical model of lipoprotein metabolism derived by combining a cascading process in the blood stream and cellular level regulatory dynamics. We analyse the existence and stability of equilibria and show that this low-dimensional, nonlinear model exhibits bistability between a low and a high cholesterol state. A sensitivity analysis indicates that the intracellular concentration of cholesterol is robust to parametric variations while the plasma cholesterol can vary widely. We show how the dynamical response to time-dependent inputs can be used to diagnose the state of the system. We also establish the connection between parameters in the system and medical and genetic conditions.
AU - August,E
AU - Parker,KH
AU - Barahona,M
DO - 10.1007/s11538-006-9132-6
EP - 1254
PY - 2006///
SN - 0092-8240
SP - 1233
TI - A dynamical model of lipoprotein metabolism
T2 - BULLETIN OF MATHEMATICAL BIOLOGY
UR - http://dx.doi.org/10.1007/s11538-006-9132-6
UR - http://hdl.handle.net/10044/1/10251
VL - 69
ER -