@article{Tenland:2018:10.1016/j.tube.2018.10.008,
author = {Tenland, E and Krishnan, N and Rönnholm, A and Kalsum, S and Puthia, M and Mörgelin, M and Davoudi, M and Otrocka, M and Alaridah, N and Glegola-Madejska, I and Sturegård, E and Schmidtchen, A and Lerm, M and Robertson, BD and Godaly, G},
doi = {10.1016/j.tube.2018.10.008},
journal = {Tuberculosis},
pages = {231--238},
title = {A novel derivative of the fungal antimicrobial peptide plectasin is active against Mycobacterium tuberculosis},
url = {http://dx.doi.org/10.1016/j.tube.2018.10.008},
volume = {113},
year = {2018}
}

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TY  - JOUR
AB  - Tuberculosis has been reaffirmed as the infectious disease causing most deaths in the world. Co-infection with HIV and the increase in multi-drug resistant Mycobacterium tuberculosis strains complicate treatment and increases mortality rates, making the development of new drugs an urgent priority. In this study we have identified a promising candidate by screening antimicrobial peptides for their capacity to inhibit mycobacterial growth. This non-toxic peptide, NZX, is capable of inhibiting both clinical strains of M. tuberculosis and an MDR strain at therapeutic concentrations. The therapeutic potential of NZX is further supported in vivo where NZX significantly lowered the bacterial load with only five days of treatment, comparable to rifampicin treatment over the same period. NZX possesses intracellular inhibitory capacity and co-localizes with intracellular bacteria in infected murine lungs. In conclusion, the data presented strongly supports the therapeutic potential of NZX in future anti-TB treatment.
AU  - Tenland,E
AU  - Krishnan,N
AU  - Rönnholm,A
AU  - Kalsum,S
AU  - Puthia,M
AU  - Mörgelin,M
AU  - Davoudi,M
AU  - Otrocka,M
AU  - Alaridah,N
AU  - Glegola-Madejska,I
AU  - Sturegård,E
AU  - Schmidtchen,A
AU  - Lerm,M
AU  - Robertson,BD
AU  - Godaly,G
DO  - 10.1016/j.tube.2018.10.008
EP  - 238
PY  - 2018///
SN  - 1472-9792
SP  - 231
TI  - A novel derivative of the fungal antimicrobial peptide plectasin is active against Mycobacterium tuberculosis
T2  - Tuberculosis
UR  - http://dx.doi.org/10.1016/j.tube.2018.10.008
UR  - http://hdl.handle.net/10044/1/64786
VL  - 113
ER  - 

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