@article{Balaban:2019:10.1038/s41579-019-0196-3,
author = {Balaban, NQ and Helaine, S and Lewis, K and Ackermann, M and Aldridge, B and Andersson, DI and Brynildsen, MP and Bumann, D and Camilli, A and Collins, JJ and Dehio, C and Fortune, S and Ghigo, J-M and Hardt, W-D and Harms, A and Heinemann, M and Hung, DT and Jenal, U and Levin, BR and Michiels, J and Storz, G and Tan, M-W and Tenson, T and Van, Melderen L and Zinkernagel, A},
doi = {10.1038/s41579-019-0196-3},
journal = {Nature Reviews Microbiology},
pages = {441--448},
title = {Definitions and guidelines for research on antibiotic persistence},
url = {http://dx.doi.org/10.1038/s41579-019-0196-3},
volume = {17},
year = {2019}
}

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TY  - JOUR
AB  - Increasing concerns about the rising rates of antibiotic therapy failure and advances in single-cell analyses have inspired a surge of research into antibiotic persistence. Bacterial persister cells represent a subpopulation of cells that can survive intensive antibiotic treatment without being resistant. Several approaches have emerged to define and measure persistence, and it is now time to agree on the basic definition of persistence and its relation to the other mechanisms by which bacteria survive exposure to bactericidal antibiotic treatments, such as antibiotic resistance, heteroresistance or tolerance. In this Consensus Statement, we provide definitions of persistence phenomena, distinguish between triggered and spontaneous persistence and provide a guide to measuring persistence. Antibiotic persistence is not only an interesting example of non-genetic single-cell heterogeneity, it may also have a role in the failure of antibiotic treatments. Therefore, it is our hope that the guidelines outlined in this article will pave the way for better characterization of antibiotic persistence and for understanding its relevance to clinical outcomes.
AU  - Balaban,NQ
AU  - Helaine,S
AU  - Lewis,K
AU  - Ackermann,M
AU  - Aldridge,B
AU  - Andersson,DI
AU  - Brynildsen,MP
AU  - Bumann,D
AU  - Camilli,A
AU  - Collins,JJ
AU  - Dehio,C
AU  - Fortune,S
AU  - Ghigo,J-M
AU  - Hardt,W-D
AU  - Harms,A
AU  - Heinemann,M
AU  - Hung,DT
AU  - Jenal,U
AU  - Levin,BR
AU  - Michiels,J
AU  - Storz,G
AU  - Tan,M-W
AU  - Tenson,T
AU  - Van,Melderen L
AU  - Zinkernagel,A
DO  - 10.1038/s41579-019-0196-3
EP  - 448
PY  - 2019///
SN  - 1740-1526
SP  - 441
TI  - Definitions and guidelines for research on antibiotic persistence
T2  - Nature Reviews Microbiology
UR  - http://dx.doi.org/10.1038/s41579-019-0196-3
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30980069
UR  - http://hdl.handle.net/10044/1/70040
VL  - 17
ER  - 

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