@article{Gonzalez:2019:10.1016/j.tim.2019.05.009,
author = {Gonzalez, D and Mavridou, D},
doi = {10.1016/j.tim.2019.05.009},
journal = {Trends in Microbiology},
pages = {897--905},
title = {Making the best of aggression, the many dimensions of bacterial toxin regulation},
url = {http://dx.doi.org/10.1016/j.tim.2019.05.009},
volume = {27},
year = {2019}
}

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TY  - JOUR
AB  - Most bacteria use toxins to exclude competitors.As the synthesis  and  delivery of  these moleculesentail considerablecostsfor the producers, theirexpressionis tightly regulated, often by molecular systems detecting physiological stressesor environment-specific cues.However, the ecological connection between such systemsand competitive behaviorsis not always clear. Here,  we  review  the  regulation  of  antibacterial  toxins  and  propose  a  conceptual  framework organizing the decision-making processes controlling toxin production. As bacteria are unable to precisely identify their competitors,we argue  that toxin regulation primarily responds  to cues directly or indirectly associated with the presence of competing strains. The density and fitnessof the producing populational so play a role in the decision-making process.Overall, we contendthat optimal toxin production strategies involvemonitoring of both self and foe.
AU  - Gonzalez,D
AU  - Mavridou,D
DO  - 10.1016/j.tim.2019.05.009
EP  - 905
PY  - 2019///
SN  - 0966-842X
SP  - 897
TI  - Making the best of aggression, the many dimensions of bacterial toxin regulation
T2  - Trends in Microbiology
UR  - http://dx.doi.org/10.1016/j.tim.2019.05.009
UR  - http://hdl.handle.net/10044/1/70695
VL  - 27
ER  - 

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