In this section
@article{Wang:2019:10.7554/elife.49570,
author = {Wang, R and Kreutzfeldt, K and Botella, H and Vaubourgeix, J and Schnappinger, D and Ehrt, S},
doi = {10.7554/elife.49570},
journal = {eLife},
pages = {1--21},
title = {Persistent mycobacterium tuberculosis infection in mice requires PerM for successful cell division},
url = {http://dx.doi.org/10.7554/elife.49570},
volume = {8},
year = {2019}
}
TY - JOUR
AB - The ability of Mycobacterium tuberculosis (Mtb) to persist in its host is central to thepathogenesis of tuberculosis, yet the underlying mechanisms remain incompletely defined. PerM,an integral membrane protein, is required for persistence of Mtb in mice. Here, we show that perMdeletion caused a cell division defect specifically during the chronic phase of mouse infection, butdid not affect Mtb’s cell replication during acute infection. We further demonstrate that PerM isrequired for cell division in chronically infected mice and in vitro under host-relevant stressesbecause it is part of the mycobacterial divisome and stabilizes the essential divisome protein FtsB.These data highlight the importance of sustained cell division for Mtb persistence, define conditionspecific requirements for cell division and reveal that survival of Mtb during chronic infectiondepends on a persistence divisome.
AU - Wang,R
AU - Kreutzfeldt,K
AU - Botella,H
AU - Vaubourgeix,J
AU - Schnappinger,D
AU - Ehrt,S
DO - 10.7554/elife.49570
EP - 21
PY - 2019///
SN - 2050-084X
SP - 1
TI - Persistent mycobacterium tuberculosis infection in mice requires PerM for successful cell division
T2 - eLife
UR - http://dx.doi.org/10.7554/elife.49570
UR - https://elifesciences.org/articles/49570
UR - http://hdl.handle.net/10044/1/75086
VL - 8
ER -
CBRB
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