@article{Prasad:2020:10.1111/febs.15198,
author = {Prasad, H and Shenoy, AR and Visweswariah, SS},
doi = {10.1111/febs.15198},
journal = {The Federation of European Biochemical Societies (FEBS) Journal},
pages = {1970--1981},
title = {Cyclic nucleotides, gut physiology and inflammation},
url = {http://dx.doi.org/10.1111/febs.15198},
volume = {287},
year = {2020}
}

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TY  - JOUR
AB  - Misregulation of gut function and homeostasis impinges on the overall wellbeing of the entire organism. Diarrheal disease is the second leading cause of death in children under 5 years of age, and globally, 1.7 billion cases of childhood diarrhea are reported every year. Accompanying diarrheal episodes are a number of secondary effects in gut physiology and structure, such as erosion of the mucosal barrier that lines the gut, facilitating further inflammation of the gut in response to the normal microbiome. Here, we focus on pathogenic bacteriamediated diarrhea, emphasizing the role of cyclic adenosine 3',5'monophosphate and cyclic guanosine 3′,5′monophosphate in driving signaling outputs that result in the secretion of water and ions from the epithelial cells of the gut. We also speculate on how this aberrant efflux and influx of ions could modulate inflammasome signaling, and therefore cell survival and maintenance of gut architecture and function.
AU  - Prasad,H
AU  - Shenoy,AR
AU  - Visweswariah,SS
DO  - 10.1111/febs.15198
EP  - 1981
PY  - 2020///
SN  - 1742-464X
SP  - 1970
TI  - Cyclic nucleotides, gut physiology and inflammation
T2  - The Federation of European Biochemical Societies (FEBS) Journal
UR  - http://dx.doi.org/10.1111/febs.15198
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000506923700001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15198
UR  - http://hdl.handle.net/10044/1/76606
VL  - 287
ER  - 

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