@article{Vincent:2020:10.1101/2020.08.12.247965,
author = {Vincent, CM and Dionne, MS},
doi = {10.1101/2020.08.12.247965},
title = {Disparate regulation of <i>imd</i> drives sex differences in infection pathology in <i>Drosophila melanogaster</i>},
url = {http://dx.doi.org/10.1101/2020.08.12.247965},
year = {2020}
}

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TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:p>Male and female animals exhibit differences in infection outcomes. One possible source of sexually dimorphic immunity is sex-specific costs of immune activity or pathology, but little is known about the independent effects of immune-induced versus microbe-induced pathology, and whether these may differ for the sexes. Here, through measuring metabolic and physiological outputs in wild-type and immune-compromised <jats:italic>Drosophila melanogaster</jats:italic>, we test whether the sexes are differentially impacted by these various sources of pathology and identify a critical regulator of this difference. We find that the sexes exhibit differential immune activity but similar bacteria-derived metabolic pathology. We show that female-specific immune-inducible expression of <jats:italic>PGRP-LB</jats:italic>, a negative regulator of the Imd pathway, enables females to reduce immune activity in response to reductions in bacterial numbers. In the absence of <jats:italic>PGRP-LB</jats:italic>, females are more resistant of infection, confirming the functional importance of this regulation and suggesting that female-biased immune restriction comes at a cost.</jats:p>
AU  - Vincent,CM
AU  - Dionne,MS
DO  - 10.1101/2020.08.12.247965
PY  - 2020///
TI  - Disparate regulation of <i>imd</i> drives sex differences in infection pathology in <i>Drosophila melanogaster</i>
UR  - http://dx.doi.org/10.1101/2020.08.12.247965
ER  - 

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