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@article{Vincent:2020:10.1101/2020.08.12.247965,
author = {Vincent, CM and Dionne, MS},
doi = {10.1101/2020.08.12.247965},
title = {Disparate regulation of<i>imd</i>drives sex differences in infection pathology in<i>Drosophila melanogaster</i>},
url = {http://dx.doi.org/10.1101/2020.08.12.247965},
year = {2020}
}
TY - JOUR
AB - <jats:title>Abstract</jats:title><jats:p>Male and female animals exhibit differences in infection outcomes. One possible source of sexually dimorphic immunity is sex-specific costs of immune activity or pathology, but little is known about the independent effects of immune-induced versus microbe-induced pathology, and whether these may differ for the sexes. Here, through measuring metabolic and physiological outputs in wild-type and immune-compromised<jats:italic>Drosophila melanogaster</jats:italic>, we test whether the sexes are differentially impacted by these various sources of pathology and identify a critical regulator of this difference. We find that the sexes exhibit differential immune activity but similar bacteria-derived metabolic pathology. We show that female-specific immune-inducible expression of<jats:italic>PGRP-LB</jats:italic>, a negative regulator of the Imd pathway, enables females to reduce immune activity in response to reductions in bacterial numbers. In the absence of<jats:italic>PGRP-LB</jats:italic>, females are more resistant of infection, confirming the functional importance of this regulation and suggesting that female-biased immune restriction comes at a cost.</jats:p>
AU - Vincent,CM
AU - Dionne,MS
DO - 10.1101/2020.08.12.247965
PY - 2020///
TI - Disparate regulation of<i>imd</i>drives sex differences in infection pathology in<i>Drosophila melanogaster</i>
UR - http://dx.doi.org/10.1101/2020.08.12.247965
ER -
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