In this section
@article{Vincent:2021:10.1073/pnas.2026554118,
author = {Vincent, CM and Dionne, MS},
doi = {10.1073/pnas.2026554118},
journal = {Proceedings of the National Academy of Sciences},
pages = {1--10},
title = {Disparate regulation of IMD signaling drives sex differences in infection pathology in Drosophila melanogaster},
url = {http://dx.doi.org/10.1073/pnas.2026554118},
volume = {118},
year = {2021}
}
TY - JOUR
AB - Male and female animals exhibit differences in infection outcomes. One possible source of sexually dimorphic immunity is the sex-specific costs of immune activity or pathology, but little is known about the independent effects of immune- versus microbe-induced pathology and whether these may differ for the sexes. Here, by measuring metabolic and physiological outputs in Drosophila melanogaster with wild-type and mutant immune responses, we test whether the sexes are differentially impacted by these various sources of pathology and identify a critical regulator of this difference. We find that the sexes exhibit differential immune activity but similar bacteria-derived metabolic pathology. We show that female-specific immune-inducible expression of PGRP-LB, a negative regulator of the immune deficiency (IMD) pathway, enables females to reduce immune activity in response to reductions in bacterial numbers. In the absence of PGRP-LB, females are more resistant to infection, confirming the functional importance of this regulation and suggesting that female-biased immune restriction comes at a cost.
AU - Vincent,CM
AU - Dionne,MS
DO - 10.1073/pnas.2026554118
EP - 10
PY - 2021///
SN - 0027-8424
SP - 1
TI - Disparate regulation of IMD signaling drives sex differences in infection pathology in Drosophila melanogaster
T2 - Proceedings of the National Academy of Sciences
UR - http://dx.doi.org/10.1073/pnas.2026554118
UR - https://www.pnas.org/content/118/32/e2026554118
UR - http://hdl.handle.net/10044/1/90820
VL - 118
ER -
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