@article{Vincent:2021:10.1073/pnas.2026554118,
author = {Vincent, CM and Dionne, MS},
doi = {10.1073/pnas.2026554118},
journal = {Proceedings of the National Academy of Sciences},
pages = {1--10},
title = {Disparate regulation of IMD signaling drives sex differences in infection pathology in Drosophila melanogaster},
url = {http://dx.doi.org/10.1073/pnas.2026554118},
volume = {118},
year = {2021}
}

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TY  - JOUR
AB  - Male and female animals exhibit differences in infection outcomes. One possible source of sexually dimorphic immunity is the sex-specific costs of immune activity or pathology, but little is known about the independent effects of immune- versus microbe-induced pathology and whether these may differ for the sexes. Here, by measuring metabolic and physiological outputs in Drosophila melanogaster with wild-type and mutant immune responses, we test whether the sexes are differentially impacted by these various sources of pathology and identify a critical regulator of this difference. We find that the sexes exhibit differential immune activity but similar bacteria-derived metabolic pathology. We show that female-specific immune-inducible expression of PGRP-LB, a negative regulator of the immune deficiency (IMD) pathway, enables females to reduce immune activity in response to reductions in bacterial numbers. In the absence of PGRP-LB, females are more resistant to infection, confirming the functional importance of this regulation and suggesting that female-biased immune restriction comes at a cost.
AU  - Vincent,CM
AU  - Dionne,MS
DO  - 10.1073/pnas.2026554118
EP  - 10
PY  - 2021///
SN  - 0027-8424
SP  - 1
TI  - Disparate regulation of IMD signaling drives sex differences in infection pathology in Drosophila melanogaster
T2  - Proceedings of the National Academy of Sciences
UR  - http://dx.doi.org/10.1073/pnas.2026554118
UR  - https://www.pnas.org/content/118/32/e2026554118
UR  - http://hdl.handle.net/10044/1/90820
VL  - 118
ER  - 

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