@article{Yebra:2020:10.1101/2020.10.13.331058,
author = {Yebra, G and Haag, AF and Neamah, MM and Wee, BA and Richardson, EJ and Horcajo, P and Granneman, S and Tormo-Más, MÁ and de, la Fuente R and Fitzgerald, JR and Penadés, JR},
doi = {10.1101/2020.10.13.331058},
title = {Massive genome decay and insertion sequence expansion drive the evolution of a novel host-restricted bacterial pathogen},
url = {http://dx.doi.org/10.1101/2020.10.13.331058},
year = {2020}
}

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TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>The emergence of new pathogens is a major threat to public and veterinary health. Changes in bacterial habitat such as those associated with a switch in host or disease tropism are often accompanied by genetic adaptation. <jats:italic>Staphylococcus aureus</jats:italic> is a multi-host bacterial species comprising strains with distinct tropisms for human and livestock species. A microaerophilic subspecies, <jats:italic>Staphylococcus aureus</jats:italic> subsp. <jats:italic>anaerobius</jats:italic>, is responsible for outbreaks of Morel’s disease, a lymphadenitis in small ruminants. However, the evolutionary history of <jats:italic>S. aureus</jats:italic> subsp. <jats:italic>anaerobius</jats:italic> and its relatedness to <jats:italic>S. aureus</jats:italic> are unknown.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Evolutionary genomic analyses of clinical <jats:italic>S. aureus</jats:italic> subsp. <jats:italic>anaerobius</jats:italic> isolates revealed a highly conserved clone that descended from a <jats:italic>S. aureus</jats:italic> progenitor about 1000 years ago before differentiating into distinct lineages representing African and European isolates. <jats:italic>S. aureus</jats:italic> subsp. <jats:italic>anaerobius</jats:italic> has undergone limited clonal expansion, with a restricted population size, and an evolutionary rate 10-fold slower than <jats:italic>S. aureus</jats:italic>. The transition to its current restricted ecological niche involved acquisition of a pathogenicity island encoding a ruminant host-specific effector of abscess formation, several large chromosomal re-arrangements, and the accumulation of at least 205 pse
AU  - Yebra,G
AU  - Haag,AF
AU  - Neamah,MM
AU  - Wee,BA
AU  - Richardson,EJ
AU  - Horcajo,P
AU  - Granneman,S
AU  - Tormo-Más,MÁ
AU  - de,la Fuente R
AU  - Fitzgerald,JR
AU  - Penadés,JR
DO  - 10.1101/2020.10.13.331058
PY  - 2020///
TI  - Massive genome decay and insertion sequence expansion drive the evolution of a novel host-restricted bacterial pathogen
UR  - http://dx.doi.org/10.1101/2020.10.13.331058
ER  - 

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