@article{Lee:2021:10.1099/mgen.0.000658,
author = {Lee, WWY and Mattock, J and Greig, DR and Langridge, GC and Baker, D and Bloomfield, S and Mather, AE and Wain, JR and Edwards, AM and Hartman, H and Dallman, TJ and Chattaway, MA and Nair, S},
doi = {10.1099/mgen.0.000658},
journal = {Microbial Genomics},
pages = {1--11},
title = {Characterization of a pESI- like plasmid and analysis of multidrug-resistant Salmonella enterica Infantis isolates in England and Wales},
url = {http://dx.doi.org/10.1099/mgen.0.000658},
volume = {7},
year = {2021}
}

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TY  - JOUR
AB  - Salmonella enterica serovar Infantis is the fifth most common Salmonella serovar isolated in England and Wales. Epidemiological, genotyping and antimicrobial-resistance data for S. enterica Infantis isolates were used to analyse English and Welsh demographics over a 5 year period. Travel cases associated with S. enterica Infantis were mainly from Asia, followed by cases from Europe and North America. Since 2000, increasing numbers of S. enterica Infantis had multidrug resistance determinants harboured on a large plasmid termed ‘plasmid of emerging S. enterica Infantis’ (pESI). Between 2013 and 2018, 42 S. enterica Infantis isolates were isolated from humans and food that harboured resistance determinants to multiple antimicrobial classes present on a pESI-like plasmid, including extended-spectrum β-lactamases (ESBLs; blaCTX-M-65). Nanopore sequencing of an ESBL-producing human S. enterica Infantis isolate indicated the presence of two regions on an IncFIB pESI-like plasmid harbouring multiple resistance genes. Phylogenetic analysis of the English and Welsh S. enterica Infantis population indicated that the majority of multidrug-resistant isolates harbouring the pESI-like plasmid belonged to a single clade maintained within the population. The blaCTX-M-65 ESBL isolates first isolated in 2013 comprise a lineage within this clade, which was mainly associated with South America. Our data, therefore, show the emergence of a stable resistant clone that has been in circulation for some time in the human population in England and Wales, highlighting the necessity of monitoring resistance in this serovar.
AU  - Lee,WWY
AU  - Mattock,J
AU  - Greig,DR
AU  - Langridge,GC
AU  - Baker,D
AU  - Bloomfield,S
AU  - Mather,AE
AU  - Wain,JR
AU  - Edwards,AM
AU  - Hartman,H
AU  - Dallman,TJ
AU  - Chattaway,MA
AU  - Nair,S
DO  - 10.1099/mgen.0.000658
EP  - 11
PY  - 2021///
SN  - 2057-5858
SP  - 1
TI  - Characterization of a pESI- like plasmid and analysis of multidrug-resistant Salmonella enterica Infantis isolates in England and Wales
T2  - Microbial Genomics
UR  - http://dx.doi.org/10.1099/mgen.0.000658
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000715055900010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.microbiologyresearch.org/content/journal/mgen/10.1099/mgen.0.000658
UR  - http://hdl.handle.net/10044/1/96260
VL  - 7
ER  - 

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