BibTex format
@article{Kreutzberger:2022:10.1038/s41467-022-29069-y,
author = {Kreutzberger, MAB and Sobe, RC and Sauder, AB and Chatterjee, S and Peña, A and Wang, F and Giron, JA and Kiessling, V and Costa, TRD and Conticello, VP and Frankel, G and Kendall, MM and Scharf, BE and Egelman, EH},
doi = {10.1038/s41467-022-29069-y},
journal = {Nature Communications},
pages = {1--13},
title = {Flagellin outer domain dimerization modulates motility in pathogenic and soil bacteria from viscous environments.},
url = {http://dx.doi.org/10.1038/s41467-022-29069-y},
volume = {13},
year = {2022}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Flagellar filaments function as the propellers of the bacterial flagellum and their supercoiling is key to motility. The outer domains on the surface of the filament are non-critical for motility in many bacteria and their structures and functions are not conserved. Here, we show the atomic cryo-electron microscopy structures for flagellar filaments from enterohemorrhagic Escherichia coli O157:H7, enteropathogenic E. coli O127:H6, Achromobacter, and Sinorhizobium meliloti, where the outer domains dimerize or tetramerize to form either a sheath or a screw-like surface. These dimers are formed by 180° rotations of half of the outer domains. The outer domain sheath (ODS) plays a role in bacterial motility by stabilizing an intermediate waveform and prolonging the tumbling of E. coli cells. Bacteria with these ODS and screw-like flagellar filaments are commonly found in soil and human intestinal environments of relatively high viscosity suggesting a role for the dimerization in these environments.
AU - Kreutzberger,MAB
AU - Sobe,RC
AU - Sauder,AB
AU - Chatterjee,S
AU - Peña,A
AU - Wang,F
AU - Giron,JA
AU - Kiessling,V
AU - Costa,TRD
AU - Conticello,VP
AU - Frankel,G
AU - Kendall,MM
AU - Scharf,BE
AU - Egelman,EH
DO - 10.1038/s41467-022-29069-y
EP - 13
PY - 2022///
SN - 2041-1723
SP - 1
TI - Flagellin outer domain dimerization modulates motility in pathogenic and soil bacteria from viscous environments.
T2 - Nature Communications
UR - http://dx.doi.org/10.1038/s41467-022-29069-y
UR - https://www.ncbi.nlm.nih.gov/pubmed/35301306
UR - https://www.nature.com/articles/s41467-022-29069-y
UR - http://hdl.handle.net/10044/1/95934
VL - 13
ER -
