Citation

BibTex format

@article{Tonkin:2022:10.1002/adhm.202200036,
author = {Tonkin, R and Kloeckner, A and Najer, A and Simoes, da Silva CJ and Echalier, C and Dionne, MS and Edwards, AM and Stevens, M},
doi = {10.1002/adhm.202200036},
journal = {Advanced Healthcare Materials},
pages = {1--14},
title = {Bacterial toxin-triggered release of antibiotics from capsosomes protects a fly model from lethal methicillin-resistant Staphylococcus aureus (MRSA) infection},
url = {http://dx.doi.org/10.1002/adhm.202200036},
volume = {11},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Antibiotic resistance is a severe global health threat and hence demands rapid action to develop novel therapies, including microscale drug delivery systems. Herein, a hierarchical microparticle system is developed to achieve bacteria-activated single- and dual-antibiotic drug delivery for preventing methicillin-resistant Staphylococcus aureus (MRSA) bacterial infections. The designed system is based on a capsosome structure, which consists of a mesoporous silica microparticle coated in alternating layers of oppositely charged polymers and antibiotic-loaded liposomes. The capsosomes are engineered and shown to release their drug payloads in the presence of MRSA toxins controlled by the Agr quorum sensing system. MRSA-activated single drug delivery of vancomycin and synergistic dual delivery of vancomycin together with an antibacterial peptide successfully kills MRSA in vitro. The capability of capsosomes to selectively deliver their cargo in the presence of bacteria, producing a bactericidal effect to protect the host organism, is confirmed in vivo using a Drosophila melanogaster MRSA infection model. Thus, the capsosomes serve as a versatile multidrug, subcompartmentalized microparticle system for preventing antibiotic-resistant bacterial infections, with potential applications to protect wounds or medical device implants from infections.
AU  - Tonkin,R
AU  - Kloeckner,A
AU  - Najer,A
AU  - Simoes,da Silva CJ
AU  - Echalier,C
AU  - Dionne,MS
AU  - Edwards,AM
AU  - Stevens,M
DO  - 10.1002/adhm.202200036
EP  - 14
PY  - 2022///
SN  - 2192-2640
SP  - 1
TI  - Bacterial toxin-triggered release of antibiotics from capsosomes protects a fly model from lethal methicillin-resistant Staphylococcus aureus (MRSA) infection
T2  - Advanced Healthcare Materials
UR  - http://dx.doi.org/10.1002/adhm.202200036
UR  - https://onlinelibrary.wiley.com/doi/10.1002/adhm.202200036
UR  - http://hdl.handle.net/10044/1/97067
VL  - 11
ER  -
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