In this section
@article{Fillol-Salom:2022:10.1016/j.cell.2022.07.014,
author = {Fillol-Salom, A and Rostøl, JT and Ojiogu, AD and Chen, J and Douce, G and Humphrey, S and Penadés, JR},
doi = {10.1016/j.cell.2022.07.014},
journal = {Cell},
pages = {3248--3262.e20},
title = {Bacteriophages benefit from mobilizing pathogenicity islands encoding immune systems against competitors},
url = {http://dx.doi.org/10.1016/j.cell.2022.07.014},
volume = {185},
year = {2022}
}
TY - JOUR
AB - Bacteria encode sophisticated anti-phage systems that are diverse and versatile and display high genetic mobility. How this variability and mobility occurs remains largely unknown. Here, we demonstrate that a widespread family of pathogenicity islands, the phage-inducible chromosomal islands (PICIs), carry an impressive arsenal of defense mechanisms, which can be disseminated intra- and inter-generically by helper phages. These defense systems provide broad immunity, blocking not only phage reproduction, but also plasmid and non-cognate PICI transfer. Our results demonstrate that phages can mobilize PICI-encoded immunity systems to use them against other mobile genetic elements, which compete with the phages for the same bacterial hosts. Therefore, despite the cost, mobilization of PICIs may be beneficial for phages, PICIs, and bacteria in nature. Our results suggest that PICIs are important players controlling horizontal gene transfer and that PICIs and phages establish mutualistic interactions that drive bacterial ecology and evolution.
AU - Fillol-Salom,A
AU - Rostøl,JT
AU - Ojiogu,AD
AU - Chen,J
AU - Douce,G
AU - Humphrey,S
AU - Penadés,JR
DO - 10.1016/j.cell.2022.07.014
EP - 3262
PY - 2022///
SN - 0092-8674
SP - 3248
TI - Bacteriophages benefit from mobilizing pathogenicity islands encoding immune systems against competitors
T2 - Cell
UR - http://dx.doi.org/10.1016/j.cell.2022.07.014
UR - https://www.ncbi.nlm.nih.gov/pubmed/35985290
UR - http://hdl.handle.net/10044/1/99349
VL - 185
ER -
CBRB
Imperial College London
Flowers Building
Exhibition Road
London SW7 2AZ
