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• Journal article
  Painter KL, Strange E, Parkhill J, Bamford KB, Armstrong-James D, Edwards AMet al., 2015,

  Staphylococcus aureus adapts to oxidative stress by producing H2O2-resistant small colony variants via the SOS response

  , Infection and Immunity, ISSN: 1098-5522
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• Journal article
  Evans ML, Chorell E, Taylor JD, Aden J, Gotheson A, Li F, Koch M, Sefer L, Matthews SJ, Wittung-Stafshede P, Almqvist F, Chapman MRet al., 2015,

  The Bacterial Curli System Possesses a Potent and Selective Inhibitor of Amyloid Formation

  , MOLECULAR CELL, Vol: 57, Pages: 445-455, ISSN: 1097-2765
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  • Citations: 138
• Journal article
  Torres M, Garcia-Garcia L, Cruz-Hervert P, Guio H, Carranza C, Ferreyra-Reyes L, Canizales S, Molina S, Ferreira-Guerrero E, Tellez N, Montero-Campos R, Delgado-Sanchez G, Mongua-Rodriguez N, Sifuentes-Osornio J, Ponce-de Leon A, Sada E, Young DB, Wilkinson RJet al., 2015,

  Effect of isoniazid on antigen-specific interferon-γ secretion in latent tuberculosis

  , EUROPEAN RESPIRATORY JOURNAL, Vol: 45, Pages: 473-482, ISSN: 0903-1936
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  • Citations: 10
• Journal article
  Eldridge MJG, Shenoy AR, 2015,

  Antimicrobial inflammasomes: unified signalling against diverse bacterial pathogens

  , CURRENT OPINION IN MICROBIOLOGY, Vol: 23, Pages: 32-41, ISSN: 1369-5274
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  • Citations: 30
• Journal article
  Holden DW, Philpott DJ, 2015,

  Editorial overview: Host-microbe interactions: bacteria

  , CURRENT OPINION IN MICROBIOLOGY, Vol: 23, Pages: V-VIII, ISSN: 1369-5274
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• Journal article
  Campeotto I, Zhang Y, Mladenov MG, Freemont PS, Grundling Aet al., 2015,

  Complex Structure and Biochemical Characterization of the Staphylococcus aureus Cyclic Diadenylate Monophosphate (c-di-AMP)-binding Protein PstA, the Founding Member of a New Signal Transduction Protein Family

  , Journal of Biological Chemistry, Vol: 290, Pages: 2888-2901, ISSN: 1083-351X

  Signaling nucleotides are integral parts of signal transductionsystems allowing bacteria to cope with and rapidly respond tochanges in the environment. The Staphylococcus aureus PII-likesignal transduction protein PstA was recently identified as acyclic diadenylate monophosphate (c-di-AMP)-binding protein.Here, we present the crystal structures of the apo- and c-diAMP-boundPstA protein, which is trimeric in solution as wellas in the crystals. The structures combined with detailed bioinformaticsanalysis revealed that the protein belongs to a newfamily of proteins with a similar core fold but with distinct featuresto classical PII proteins, which usually function in nitrogenmetabolism pathways in bacteria. The complex structurerevealed three identical c-di-AMP-binding sites per trimer witheach binding site at a monomer-monomer interface. Althoughdistinctly different from other cyclic-di-nucleotide-bindingsites, as the half-binding sites are not symmetrical, the complexstructure also highlighted common features for c-di-AMPbindingsites. A comparison between the apo and complexstructures revealed a series of conformational changes thatresult in the ordering of two anti-parallel !-strands that protrudefrom each monomer and allowed us to propose a mechanismon how the PstA protein functions as a signaling transductionprotein.

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• Journal article
  Schreiber F, Kay S, Frankel G, Clare S, Goulding D, van de Vosse E, van Dissel JT, Strugnell R, Thwaites G, Kingsley RA, Dougan G, Baker Set al., 2015,

  The H<i>d</i>, H<i>j</i>, and H<i>z66</i> flagella variants of <i>Salmonella enterica</i> serovar Typhi modify host responses and cellular interactions

  , SCIENTIFIC REPORTS, Vol: 5, ISSN: 2045-2322
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  • Citations: 9
• Journal article
  Thomas MS, Wigneshweraraj S, 2014,

  Regulation of virulence gene expression

  , VIRULENCE, Vol: 5, Pages: 832-834, ISSN: 2150-5594
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  • Citations: 30
• Journal article
  Huynh M-H, Liu B, Henry M, Liew L, Matthews SJ, Carruthers VBet al., 2015,

  Structural Basis of <i>Toxoplasma gondii</i> MIC2-associated Protein Interaction with MIC2

  , JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 290, Pages: 1432-1441
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  • Citations: 17
• Journal article
  Woodcock KJ, Kierdorf K, Pouchelon CA, Vivancos V, Dionne MS, Geissmann Fet al., 2015,

  Macrophage-derived upd3 Cytokine causes impaired glucose homeostasis and reduced lifespan in drosophila fed a lipid-rich diet

  , Immunity, Vol: 42, Pages: 133-144, ISSN: 1097-4180

  Long-term consumption of fatty foods is associated with obesity, macrophage activation and inflammation, metabolic imbalance, and a reduced lifespan. We took advantage of Drosophila genetics to investigate the role of macrophages and the pathway(s) that govern their response to dietary stress. Flies fed a lipid-rich diet presented with increased fat storage, systemic activation of JAK-STAT signaling, reduced insulin sensitivity, hyperglycemia, and a shorter lifespan. Drosophila macrophages produced the JAK-STAT-activating cytokine upd3, in a scavenger-receptor (crq) and JNK-dependent manner. Genetic depletion of macrophages or macrophage-specific silencing of upd3 decreased JAK-STAT activation and rescued insulin sensitivity and the lifespan of Drosophila, but did not decrease fat storage. NF-κB signaling made no contribution to the phenotype observed. These results identify an evolutionarily conserved “scavenger receptor-JNK-type 1 cytokine” cassette in macrophages, which controls glucose metabolism and reduces lifespan in Drosophila maintained on a lipid-rich diet via activation of the JAK-STAT pathway.

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