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• Journal article
  McEwan DG, Richter B, Claudi B, Wigge C, Wild P, Farhan H, McGourty K, Coxon FP, Franz-Wachtel M, Perdu B, Akutsu M, Habermann A, Kirchof A, Helfrich MH, Odgren PR, Van Hul W, Frangakis AS, Rajalingam K, Macek B, Holden DW, Bumann D, Dikic Iet al., 2015,

  PLEKHM1 Regulates <i>Salmonella</i>-Containing Vacuole Biogenesis and Infection

  , CELL HOST & MICROBE, Vol: 17, Pages: 58-71, ISSN: 1931-3128
  • Author Web Link
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  • Citations: 72
• Journal article
  Holden DW, 2015,

  Persisters unmasked

  , SCIENCE, Vol: 347, Pages: 30-32, ISSN: 0036-8075
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  • Citations: 23
• Journal article
  Filloux A, 2015,

  Untitled

  , FEMS MICROBIOLOGY REVIEWS, Vol: 39, Pages: 1-1, ISSN: 0168-6445
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• Journal article
  Larrouy-Maumus G, Puzo G, 2015,

  Mycobacterial envelope lipids fingerprint from direct MALDI-TOF MS analysis of intact bacilli

  , TUBERCULOSIS, Vol: 95, Pages: 75-85, ISSN: 1472-9792
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  • Citations: 22
• Book chapter
  Thurston TLM, holden DW, 2015,

  interactions between salmonella and the autophagy system

  , Autophagy, infection, and the immune response, Editors: jackson, swanson, Publisher: Wiley Blackwell, ISBN: 978-1-118-67764-3
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• Journal article
  Young JC, Clements A, Lang AE, Garnett JA, Munera D, Arbeloa A, Pearson J, Hartland EL, Matthews SJ, Mousnier A, Barry DJ, Way M, Schlosser A, Aktories K, Frankel Get al., 2014,

  The Escherichia coli effector EspJ blocks Src kinase activity via amidation and ADP ribosylation

  , Nature Communications, Vol: 5, ISSN: 2041-1723

  The hallmark of enteropathogenic Escherichia coli (EPEC) infection is the formation of actin-rich pedestal-like structures, which are generated following phosphorylation of the bacterial effector Tir by cellular Src and Abl family tyrosine kinases. This leads to recruitment of the Nck–WIP–N-WASP complex that triggers Arp2/3-dependent actin polymerization in the host cell. The same phosphorylation-mediated signalling network is also assembled downstream of the Vaccinia virus protein A36 and the phagocytic Fc-gamma receptor FcγRIIa. Here we report that the EPEC type-III secretion system effector EspJ inhibits autophosphorylation of Src and phosphorylation of the Src substrates Tir and FcγRIIa. Consistent with this, EspJ inhibits actin polymerization downstream of EPEC, Vaccinia virus and opsonized red blood cells. We identify EspJ as a unique adenosine diphosphate (ADP) ribosyltransferase that directly inhibits Src kinase by simultaneous amidation and ADP ribosylation of the conserved kinase-domain residue, Src E310, resulting in glutamine-ADP ribose.

  • Abstract
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• Journal article
  Clarke TB, 2014,

  Microbial Programming of Systemic Innate Immunity and Resistance to Infection

  , PLOS PATHOGENS, Vol: 10, ISSN: 1553-7366
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  • Citations: 33
• Journal article
  Dominguez-Huttinger E, Clarke TB, Tanaka RJ, 2014,

  Mathematical modelling of host pathogen interactions at mucosal surfaces reveals the dual role of the epithelial barrier in determining the outcome of infectious processes

  , IMMUNOLOGY, Vol: 143, Pages: 150-150, ISSN: 0019-2805
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• Journal article
  Foerster A, Planamente S, Manoli E, Lossi NS, Freemont PS, Filloux Aet al., 2014,

  Coevolution of the ATPase ClpV, the Sheath Proteins TssB and TssC, and the Accessory Protein TagJ/HsiE1 Distinguishes Type VI Secretion Classes

  , JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 289
  • Author Web Link
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  • Citations: 43
• Journal article
  Satoh-Takayama N, Serafini N, Verrier T, Rekiki A, Renauld J-C, Frankel G, Di Santo JPet al., 2014,

  The Chemokine Receptor CXCR6 Controls the Functional Topography of Interleukin-22 Producing Intestinal Innate Lymphoid Cells

  , IMMUNITY, Vol: 41, Pages: 776-788, ISSN: 1074-7613
  • Author Web Link
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  • Citations: 125

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