Publications
Results
- Showing results for:
- Reset all filters
Search results
-
Journal articleSchreiber F, Kay S, Frankel G, et al., 2015,
The H<i>d</i>, H<i>j</i>, and H<i>z66</i> flagella variants of <i>Salmonella enterica</i> serovar Typhi modify host responses and cellular interactions
, SCIENTIFIC REPORTS, Vol: 5, ISSN: 2045-2322- Author Web Link
- Open Access Link
- Cite
- Citations: 9
-
Journal articleThomas MS, Wigneshweraraj S, 2014,
Regulation of virulence gene expression
, VIRULENCE, Vol: 5, Pages: 832-834, ISSN: 2150-5594- Author Web Link
- Cite
- Citations: 30
-
Journal articleHuynh M-H, Liu B, Henry M, et al., 2015,
Structural Basis of <i>Toxoplasma gondii</i> MIC2-associated Protein Interaction with MIC2
, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 290, Pages: 1432-1441- Author Web Link
- Open Access Link
- Cite
- Citations: 17
-
Journal articleWoodcock KJ, Kierdorf K, Pouchelon CA, et al., 2015,
Macrophage-derived upd3 Cytokine causes impaired glucose homeostasis and reduced lifespan in drosophila fed a lipid-rich diet
, Immunity, Vol: 42, Pages: 133-144, ISSN: 1097-4180Long-term consumption of fatty foods is associated with obesity, macrophage activation and inflammation, metabolic imbalance, and a reduced lifespan. We took advantage of Drosophila genetics to investigate the role of macrophages and the pathway(s) that govern their response to dietary stress. Flies fed a lipid-rich diet presented with increased fat storage, systemic activation of JAK-STAT signaling, reduced insulin sensitivity, hyperglycemia, and a shorter lifespan. Drosophila macrophages produced the JAK-STAT-activating cytokine upd3, in a scavenger-receptor (crq) and JNK-dependent manner. Genetic depletion of macrophages or macrophage-specific silencing of upd3 decreased JAK-STAT activation and rescued insulin sensitivity and the lifespan of Drosophila, but did not decrease fat storage. NF-κB signaling made no contribution to the phenotype observed. These results identify an evolutionarily conserved “scavenger receptor-JNK-type 1 cytokine” cassette in macrophages, which controls glucose metabolism and reduces lifespan in Drosophila maintained on a lipid-rich diet via activation of the JAK-STAT pathway.
-
Journal articleMcEwan DG, Richter B, Claudi B, et al., 2015,
PLEKHM1 Regulates <i>Salmonella</i>-Containing Vacuole Biogenesis and Infection
, CELL HOST & MICROBE, Vol: 17, Pages: 58-71, ISSN: 1931-3128- Author Web Link
- Cite
- Citations: 72
-
Journal articleHolden DW, 2015,
Persisters unmasked
, SCIENCE, Vol: 347, Pages: 30-32, ISSN: 0036-8075- Author Web Link
- Cite
- Citations: 23
-
Journal articleFilloux A, 2015,
Untitled
, FEMS MICROBIOLOGY REVIEWS, Vol: 39, Pages: 1-1, ISSN: 0168-6445 -
Journal articleLarrouy-Maumus G, Puzo G, 2015,
Mycobacterial envelope lipids fingerprint from direct MALDI-TOF MS analysis of intact bacilli
, TUBERCULOSIS, Vol: 95, Pages: 75-85, ISSN: 1472-9792- Author Web Link
- Cite
- Citations: 22
-
Book chapterThurston TLM, holden DW, 2015,
interactions between salmonella and the autophagy system
, Autophagy, infection, and the immune response, Editors: jackson, swanson, Publisher: Wiley Blackwell, ISBN: 978-1-118-67764-3 -
Journal articleYoung JC, Clements A, Lang AE, et al., 2014,
The Escherichia coli effector EspJ blocks Src kinase activity via amidation and ADP ribosylation
, Nature Communications, Vol: 5, ISSN: 2041-1723The hallmark of enteropathogenic Escherichia coli (EPEC) infection is the formation of actin-rich pedestal-like structures, which are generated following phosphorylation of the bacterial effector Tir by cellular Src and Abl family tyrosine kinases. This leads to recruitment of the Nck–WIP–N-WASP complex that triggers Arp2/3-dependent actin polymerization in the host cell. The same phosphorylation-mediated signalling network is also assembled downstream of the Vaccinia virus protein A36 and the phagocytic Fc-gamma receptor FcγRIIa. Here we report that the EPEC type-III secretion system effector EspJ inhibits autophosphorylation of Src and phosphorylation of the Src substrates Tir and FcγRIIa. Consistent with this, EspJ inhibits actin polymerization downstream of EPEC, Vaccinia virus and opsonized red blood cells. We identify EspJ as a unique adenosine diphosphate (ADP) ribosyltransferase that directly inhibits Src kinase by simultaneous amidation and ADP ribosylation of the conserved kinase-domain residue, Src E310, resulting in glutamine-ADP ribose.
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.