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Journal articleMousnier A, Schroeder GN, Stoneham CA, et al., 2014,
A New Method To Determine <i>In Vivo</i> Interactomes Reveals Binding of the <i>Legionella pneumophila</i> Effector PieE to Multiple Rab GTPases
, MBIO, Vol: 5, ISSN: 2150-7511- Author Web Link
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- Citations: 28
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Journal articleGründling A, 2014,
Milestones in nucleotide signaling research: Nucleotide signals are found in bacteria as well as eukaryotes, and may act intra- or extracellularly
, Microbe, Vol: 9, Pages: 315-320, ISSN: 1558-7452 -
Journal articleStevens MP, Frankel GM, 2014,
The Locus of Enterocyte Effacement and Associated Virulence Factors of Enterohemorrhagic Escherichia coli.
, Microbiol Spectr, Vol: 2A subset of Shiga toxin-producing Escherichia coli strains, termed enterohemorrhagic E. coli (EHEC), is defined in part by the ability to produce attaching and effacing (A/E) lesions on intestinal epithelia. Such lesions are characterized by intimate bacterial attachment to the apical surface of enterocytes, cytoskeletal rearrangements beneath adherent bacteria, and destruction of proximal microvilli. A/E lesion formation requires the locus of enterocyte effacement (LEE), which encodes a Type III secretion system that injects bacterial proteins into host cells. The translocated proteins, termed effectors, subvert a plethora of cellular pathways to the benefit of the pathogen, for example, by recruiting cytoskeletal proteins, disrupting epithelial barrier integrity, and interfering with the induction of inflammation, phagocytosis, and apoptosis. The LEE and selected effectors play pivotal roles in intestinal persistence and virulence of EHEC, and it is becoming clear that effectors may act in redundant, synergistic, and antagonistic ways during infection. Vaccines that target the function of the Type III secretion system limit colonization of reservoir hosts by EHEC and may thus aid control of zoonotic infections. Here we review the features and functions of the LEE-encoded Type III secretion system and associated effectors of E. coli O157:H7 and other Shiga toxin-producing E. coli strains.
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Journal articleBaek KT, Grundling A, Mogensen RG, et al., 2014,
β-Lactam Resistance in Methicillin-Resistant <i>Staphylococcus aureus</i> USA300 Is Increased by Inactivation of the ClpXP Protease
, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Vol: 58, Pages: 4593-4603, ISSN: 0066-4804- Author Web Link
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- Citations: 59
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Journal articleXie H-X, Lu J-F, Rolhion N, et al., 2014,
<i>Edwardsiella tarda</i>-Induced Cytotoxicity Depends on Its Type III Secretion System and Flagellin
, INFECTION AND IMMUNITY, Vol: 82, Pages: 3436-3445, ISSN: 0019-9567- Author Web Link
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- Citations: 29
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Journal articleStramer BM, Dionne MS, 2014,
Unraveling tissue repair immune responses in flies
, SEMINARS IN IMMUNOLOGY, Vol: 26, Pages: 310-314, ISSN: 1044-5323- Author Web Link
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- Citations: 9
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Journal articleCaly DL, Coulthurst SJ, An S-Q, et al., 2014,
Communication, cooperation, and social interactions: a report from the Third Young Microbiologists Symposium on Microbe Signalling, Organisation, and Pathogenesis
, Journal of Bacteriology, Vol: 196, Pages: 3527-3533, ISSN: 1098-5530The third Young Microbiologists Symposium took place on the vibrant campus of the University of Dundee, Scotland, from the 2nd to 3rd of June 2014. The symposium attracted over 150 microbiologists from 17 different countries. The significant characteristic of this meeting was that it was specifically aimed at providing a forum for junior scientists to present their work. The meeting was supported by the Society for General Microbiology and the American Society for Microbiology, with further sponsorship from the European Molecular Biology Organization, the Federation of European Microbiological Societies, and The Royal Society of Edinburgh. In this report, we highlight some themes that emerged from the many exciting talks and poster presentations given by the young and talented microbiologists in the area of microbial gene expression, regulation, biogenesis, pathogenicity, and host interaction.
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Journal articleHelaine S, Kugelberg E, 2014,
Bacterial persisters: formation, eradication, and experimental systems
, TRENDS IN MICROBIOLOGY, Vol: 22, Pages: 417-424, ISSN: 0966-842X- Author Web Link
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- Citations: 132
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Journal articleSong-Zhao GX, Srinivasan N, Pott J, et al., 2014,
Nlrp3 activation in the intestinal epithelium protects against a mucosal pathogen
, MUCOSAL IMMUNOLOGY, Vol: 7, Pages: 763-774, ISSN: 1933-0219- Author Web Link
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- Citations: 98
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Journal articleDomingues L, Holden DW, Mota LJ, 2014,
The <i>Salmonella</i> Effector SteA Contributes to the Control of Membrane Dynamics of <i>Salmonella</i>-Containing Vacuoles
, INFECTION AND IMMUNITY, Vol: 82, Pages: 2923-2934, ISSN: 0019-9567- Author Web Link
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- Citations: 30
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