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• Journal article
  Xie H-X, Lu J-F, Rolhion N, Holden DW, Nie P, Zhou Y, Yu X-Jet al., 2014,

  <i>Edwardsiella tarda</i>-Induced Cytotoxicity Depends on Its Type III Secretion System and Flagellin

  , INFECTION AND IMMUNITY, Vol: 82, Pages: 3436-3445, ISSN: 0019-9567
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  • Citations: 29
• Journal article
  Stramer BM, Dionne MS, 2014,

  Unraveling tissue repair immune responses in flies

  , SEMINARS IN IMMUNOLOGY, Vol: 26, Pages: 310-314, ISSN: 1044-5323
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  • Citations: 9
• Journal article
  Caly DL, Coulthurst SJ, An S-Q, Helaine S, Malone JG, Ryan RPet al., 2014,

  Communication, cooperation, and social interactions: a report from the Third Young Microbiologists Symposium on Microbe Signalling, Organisation, and Pathogenesis

  , Journal of Bacteriology, Vol: 196, Pages: 3527-3533, ISSN: 1098-5530

  The third Young Microbiologists Symposium took place on the vibrant campus of the University of Dundee, Scotland, from the 2nd to 3rd of June 2014. The symposium attracted over 150 microbiologists from 17 different countries. The significant characteristic of this meeting was that it was specifically aimed at providing a forum for junior scientists to present their work. The meeting was supported by the Society for General Microbiology and the American Society for Microbiology, with further sponsorship from the European Molecular Biology Organization, the Federation of European Microbiological Societies, and The Royal Society of Edinburgh. In this report, we highlight some themes that emerged from the many exciting talks and poster presentations given by the young and talented microbiologists in the area of microbial gene expression, regulation, biogenesis, pathogenicity, and host interaction.

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• Journal article
  Helaine S, Kugelberg E, 2014,

  Bacterial persisters: formation, eradication, and experimental systems

  , TRENDS IN MICROBIOLOGY, Vol: 22, Pages: 417-424, ISSN: 0966-842X
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  • Citations: 132
• Journal article
  Song-Zhao GX, Srinivasan N, Pott J, Baban D, Frankel G, Maloy KJet al., 2014,

  Nlrp3 activation in the intestinal epithelium protects against a mucosal pathogen

  , MUCOSAL IMMUNOLOGY, Vol: 7, Pages: 763-774, ISSN: 1933-0219
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  • Citations: 98
• Journal article
  Domingues L, Holden DW, Mota LJ, 2014,

  The <i>Salmonella</i> Effector SteA Contributes to the Control of Membrane Dynamics of <i>Salmonella</i>-Containing Vacuoles

  , INFECTION AND IMMUNITY, Vol: 82, Pages: 2923-2934, ISSN: 0019-9567
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  • Citations: 30
• Journal article
  Lin J, Oh S-H, Jones R, Garnett JA, Salgado PS, Rusnakova S, Matthews SJ, Hoyer LL, Cota Eet al., 2014,

  The peptide-binding cavity Is essential for Als3-mediated adhesion of Candida albicans to human cells

  , Journal of Biological Chemistry, Vol: 289, Pages: 18401-18412, ISSN: 1083-351X

  Background: Of the eight cell surface glycoproteins in the C. albicans Als family, Als3 makes the largest contribution to adhesion to human cells.Results: Mutation of the Als3 peptide-binding cavity (PBC) results in loss of Als3 adhesive function.Conclusion: The PBC is required for Als3 adhesive function.Significance: Interfering with PBC function is a viable strategy for inhibiting C. albicans adhesion.

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• Journal article
  Ma L-S, Hachani A, Lin J-S, Filloux A, Lai E-Met al., 2014,

  Agrobacterium tumefaciens Deploys a Superfamily of Type VI Secretion DNase Effectors as Weapons for Interbacterial Competition In Planta

  , Cell Host & Microbe, Vol: 16, Pages: 94-104, ISSN: 1934-6069

  The type VI secretion system (T6SS) is a widespread molecular weapon deployed by many Proteobacteria to target effectors/toxins into both eukaryotic and prokaryotic cells. We report that Agrobacterium tumefaciens, a soil bacterium that triggers tumorigenesis in plants, produces a family of type VI DNase effectors (Tde) that are distinct from previously known polymorphic toxins and nucleases. Tde exhibits an antibacterial DNase activity that relies on a conserved HxxD motif and can be counteracted by a cognate immunity protein, Tdi. In vitro, A. tumefaciens T6SS could kill Escherichia coli but triggered a lethal counterattack by Pseudomonas aeruginosa upon injection of the Tde toxins. However, in an in planta coinfection assay, A. tumefaciens used Tde effectors to attack both siblings cells and P. aeruginosa to ultimately gain a competitive advantage. Such acquired T6SS-dependent fitness in vivo and conservation of Tde-Tdi couples in bacteria highlights a widespread antibacterial weapon beneficial for niche colonization.

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• Journal article
  Esmail H, Barry CE, Young DB, Wilkinson RJet al., 2014,

  The ongoing challenge of latent tuberculosis

  , PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Vol: 369, ISSN: 0962-8436
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  • Citations: 196
• Journal article
  Brown DR, Barton G, Pan Z, Buck M, Wigneshweraraj Set al., 2014,

  Nitrogen stress response and stringent response are coupled in Escherichia coli

  , Nature Communications, Vol: 5, ISSN: 2041-1723

  Assimilation of nitrogen is an essential process in bacteria. The nitrogen regulation stress response is an adaptive mechanism used by nitrogen-starved Escherichia coli to scavenge for alternative nitrogen sources and requires the global transcriptional regulator NtrC. In addition, nitrogen-starved E. coli cells synthesize a signal molecule, guanosine tetraphosphate (ppGpp), which serves as an effector molecule of many processes including transcription to initiate global physiological changes, collectively termed the stringent response. The regulatory mechanisms leading to elevated ppGpp levels during nutritional stresses remain elusive. Here, we show that transcription of relA, a key gene responsible for the synthesis of ppGpp, is activated by NtrC during nitrogen starvation. The results reveal that NtrC couples these two major bacterial stress responses to manage conditions of nitrogen limitation, and provide novel mechanistic insights into how a specific nutritional stress leads to elevating ppGpp levels in bacteria.

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