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Journal articleLarrouy-Maumus G, Kelly G, de Carvalho LPS, 2014,
Chemical Mechanism of Glycerol 3-Phosphate Phosphatase: pH-Dependent Changes in the Rate-Limiting Step
, BIOCHEMISTRY, Vol: 53, Pages: 143-151, ISSN: 0006-2960- Author Web Link
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- Citations: 1
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Journal articleHelaine S, Cheverton AM, Watson KG, et al., 2014,
Internalization of salmonella by macrophages induces formation of nonreplicating persisters
, SCIENCE, Vol: 343, Pages: 204-208, ISSN: 0036-8075Many bacterial pathogens cause persistent infections despite repeated antibiotic exposure. Bacterial persisters are antibiotic-tolerant cells, but little is known about their growth status and the signals and pathways leading to their formation in infected tissues. We used fluorescent single-cell analysis to identify Salmonella persisters during infection. These were part of a nonreplicating population formed immediately after uptake by macrophages and were induced by vacuolar acidification and nutritional deprivation, conditions that also induce Salmonella virulence gene expression. The majority of 14 toxin-antitoxin modules contributed to intracellular persister formation. Some persisters resumed intracellular growth after phagocytosis by naïve macrophages. Thus, the vacuolar environment induces phenotypic heterogeneity, leading to either bacterial replication or the formation of nonreplicating persisters that could provide a reservoir for relapsing infection.
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Journal articleLiu B, Shadrin A, Sheppard C, et al., 2014,
The sabotage of the bacterial transcription machinery by a small bacteriophage protein.
, Bacteriophage, Vol: 4, ISSN: 2159-7073Many bacteriophages produce small proteins that specifically interfere with the bacterial host transcription machinery and thus contribute to the acquisition of the bacterial cell by the bacteriophage. We recently described how a small protein, called P7, produced by the Xp10 bacteriophage inhibits bacterial transcription initiation by causing the dissociation of the promoter specificity sigma factor subunit from the host RNA polymerase holoenzyme. In this addendum to the original publication, we present the highlights of that research.
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Journal articleClark RI, Walker DW, Dionne MS, 2014,
Metabolic and immune integration in aging and age-related disease
, AGING-US, Vol: 6, Pages: 3-4, ISSN: 1945-4589- Author Web Link
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- Citations: 6
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Journal articlePean CB, Dionne MS, 2014,
Intracellular infections in <i>Drosophila melanogaster</i>: Host defense and mechanisms of pathogenesis
, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, Vol: 42, Pages: 57-66, ISSN: 0145-305X- Author Web Link
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- Citations: 11
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Journal articleBarraud N, Moscoso JA, Ghigo J-M, et al., 2014,
Methods for Studying Biofilm Dispersal in <i>Pseudomonas aeruginosa</i>
, PSEUDOMONAS: METHODS AND PROTOCOLS, Vol: 1149, Pages: 643-651, ISSN: 1064-3745- Author Web Link
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- Citations: 26
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Journal articlePercy MG, Gruendling A, 2014,
Lipoteichoic Acid Synthesis and Function in Gram-Positive Bacteria
, ANNUAL REVIEW OF MICROBIOLOGY, VOL 68, Vol: 68, Pages: 81-100, ISSN: 0066-4227- Author Web Link
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- Citations: 253
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Journal articlePader V, James EH, Painter KL, et al., 2014,
The Agr quorum-sensing system regulates fibronectin-binding but not hemolysis in the absence of a functional electron transport chain.
, Infection and Immunity -
Journal articleJones C, Filloux A, 2014,
Gene Amplification and qRT-PCR
, PSEUDOMONAS: METHODS AND PROTOCOLS, Vol: 1149, Pages: 457-468, ISSN: 1064-3745- Author Web Link
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- Citations: 1
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Journal articleMuhl D, Filloux A, 2014,
Site-Directed Mutagenesis and Gene Deletion Using Reverse Genetics
, PSEUDOMONAS: METHODS AND PROTOCOLS, Vol: 1149, Pages: 521-539, ISSN: 1064-3745- Author Web Link
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- Citations: 13
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