In this section
@article{Rolhion:2016:10.1371/journal.ppat.1005653,
author = {Rolhion, N and Furniss, R and Grabe, G and Ryan, A and Liu, M and Matthews, S and Holden, DW},
doi = {10.1371/journal.ppat.1005653},
journal = {Plos Pathogens},
pages = {1--26},
title = {Inhibition of nuclear transport of NF-kB p65 by the Salmonella type III secretion system effector SpvD},
url = {http://dx.doi.org/10.1371/journal.ppat.1005653},
volume = {12},
year = {2016}
}
TY - JOUR
AB - Salmonella enterica replicates in macrophages through the action of effector proteins translocated across the vacuolar membrane by a type III secretion system (T3SS). Here we show that the SPI-2 T3SS effector SpvD suppresses proinflammatory immune responses. SpvD prevented activation of an NF-B-dependent promoter and caused nuclear accumulation of importin-α, which is required for nuclear import of p65. SpvD interacted specifically with the exportin Xpo2, which mediates nuclear-cytoplasmic recycling of importins. We propose that interaction between SpvD and Xpo2 disrupts the normal recycling of importin-α from the nucleus, leading to a defect in nuclear translocation of p65 and inhibition of activation of NF-B regulated promoters. SpvD down-regulated pro-inflammatory responses and contributed to systemic growth of bacteria in mice. This work shows that a bacterial pathogen can manipulate host cell immune responses by interfering with the nuclear transport machinery.
AU - Rolhion,N
AU - Furniss,R
AU - Grabe,G
AU - Ryan,A
AU - Liu,M
AU - Matthews,S
AU - Holden,DW
DO - 10.1371/journal.ppat.1005653
EP - 26
PY - 2016///
SN - 1553-7374
SP - 1
TI - Inhibition of nuclear transport of NF-kB p65 by the Salmonella type III secretion system effector SpvD
T2 - Plos Pathogens
UR - http://dx.doi.org/10.1371/journal.ppat.1005653
UR - https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1005653
UR - http://hdl.handle.net/10044/1/32716
VL - 12
ER -
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