In this section
@article{Grundling:2016:10.1098/rstb.2015.0503,
author = {Grundling, A and Lee, V},
doi = {10.1098/rstb.2015.0503},
journal = {Philosophical Transactions of the Royal Society B: Biological Sciences},
title = {Old concepts, new molecules and current approaches applied to the bacterial nucleotide signalling field},
url = {http://dx.doi.org/10.1098/rstb.2015.0503},
volume = {371},
year = {2016}
}
TY - JOUR
AB - Signalling nucleotides are key molecules that help bacteria to rapidly coordinate cellular pathways and adaptto changes in their environment. During the past ten years, the nucleotide-signalling field has seen muchexcitement, as several new signalling nucleotides have been discovered in both eukaryotic and bacterial cells.The fields have since advanced quickly, aided by the development of important tools such as the synthesis ofmodified nucleotides, which combined with sensitive mass spectrometry methods, allowed for the rapididentification of specific receptor proteins along with other novel genome-wide screening methods. In thisreview, we will describe the principle concepts of nucleotide signalling networks and summarize the recentwork that led to the discovery of the novel signalling nucleotides. We will also highlight current approachesapplied to the research in the field as well as resources and methodological advances aiding in a rapididentification of nucleotide specific receptor proteins.
AU - Grundling,A
AU - Lee,V
DO - 10.1098/rstb.2015.0503
PY - 2016///
SN - 1471-2970
TI - Old concepts, new molecules and current approaches applied to the bacterial nucleotide signalling field
T2 - Philosophical Transactions of the Royal Society B: Biological Sciences
UR - http://dx.doi.org/10.1098/rstb.2015.0503
UR - http://hdl.handle.net/10044/1/33435
VL - 371
ER -
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