@article{Esmail:2016:10.1038/nm.4161,
author = {Esmail, H and Lai, RP and Lesosky, M and Wilkinson, KA and Graham, CM and Coussens, AK and Oni, T and Warwick, JM and Said-Hartley, Q and Koegelenberg, CF and Walzl, G and Flynn, JL and Young, DB and Barry, Iii CE and O'Garra, A and Wilkinson, RJ},
doi = {10.1038/nm.4161},
journal = {Nature Medicine},
pages = {1090--1093},
title = {Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[(18)F]fluoro-D-glucose positron emission and computed tomography},
url = {http://dx.doi.org/10.1038/nm.4161},
volume = {22},
year = {2016}
}

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TY  - JOUR
AB  - Tuberculosis is classically divided into states of latent infection and active disease. Using combined positron emission and computed tomography in 35 asymptomatic, antiretroviral-therapy-naive, HIV-1-infected adults with latent tuberculosis, we identified ten individuals with pulmonary abnormalities suggestive of subclinical, active disease who were substantially more likely to progress to clinical disease. Our findings challenge the conventional two-state paradigm and may aid future identification of biomarkers that are predictive of progression.
AU  - Esmail,H
AU  - Lai,RP
AU  - Lesosky,M
AU  - Wilkinson,KA
AU  - Graham,CM
AU  - Coussens,AK
AU  - Oni,T
AU  - Warwick,JM
AU  - Said-Hartley,Q
AU  - Koegelenberg,CF
AU  - Walzl,G
AU  - Flynn,JL
AU  - Young,DB
AU  - Barry,Iii CE
AU  - O'Garra,A
AU  - Wilkinson,RJ
DO  - 10.1038/nm.4161
EP  - 1093
PY  - 2016///
SN  - 1546-170X
SP  - 1090
TI  - Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[(18)F]fluoro-D-glucose positron emission and computed tomography
T2  - Nature Medicine
UR  - http://dx.doi.org/10.1038/nm.4161
UR  - https://www.nature.com/articles/nm.4161
UR  - http://hdl.handle.net/10044/1/42188
VL  - 22
ER  - 

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