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• Journal article
  Ho R, Hinder SJ, Watts JF, Dilworth SE, Williams DR, Heng JYYet al., 2010,

  Determination of surface heterogeneity of D-mannitol by sessile drop contact angle and finite concentration inverse gas chromatography

  , INTERNATIONAL JOURNAL OF PHARMACEUTICS, Vol: 387, Pages: 79-86, ISSN: 0378-5173
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  • Citations: 65
• Journal article
  Hare S, Gupta SS, Valkov E, Engelman A, Cherepanov Pet al., 2010,

  Retroviral intasome assembly and inhibition of DNA strand transfer

  , Nature, Vol: 464, Pages: 232-236, ISSN: 0028-0836

  Integrase is an essential retroviral enzyme that binds both termini of linear viral DNA and inserts them into a host cell chromosome. The structure of full-length retroviral integrase, either separately or in complex with DNA, has been lacking. Furthermore, although clinically useful inhibitors of HIV integrase have been developed, their mechanism of action remains speculative. Here we present a crystal structure of full-length integrase from the prototype foamy virus in complex with its cognate DNA. The structure shows the organization of the retroviral intasome comprising an integrase tetramer tightly associated with a pair of viral DNA ends. All three canonical integrase structural domains are involved in extensive protein–DNA and protein–protein interactions. The binding of strand-transfer inhibitors displaces the reactive viral DNA end from the active site, disarming the viral nucleoprotein complex. Our findings define the structural basis of retroviral DNA integration, and will allow modelling of the HIV-1 intasome to aid in the development of antiretroviral drugs.

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• Journal article
  Helaine S, Thompson JA, Watson KG, Liu M, Boyle C, Holden DWet al., 2010,

  Dynamics of intracellular bacterial replication at the single cell level

  , PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 107, Pages: 3746-3751, ISSN: 0027-8424
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  • Citations: 222
• Journal article
  Telfer A, Pascal AA, Bordes L, Barber J, Robert Bet al., 2010,

  Fluorescence Line Narrowing Studies on Isolated Chlorophyll Molecules

  , JOURNAL OF PHYSICAL CHEMISTRY B, Vol: 114, Pages: 2255-2260, ISSN: 1520-6106
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  • Citations: 14
• Journal article
  Camara B, Liu M, Reynolds J, Shadrin A, Liu B, Kwok K, Simpson P, Weinzierl R, Severinov K, Cota E, Matthews S, Wigneshweraraj SRet al., 2010,

  T7 phage protein Gp2 inhibits the <i>Escherichia coli</i> RNA polymerase by antagonizing stable DNA strand separation near the transcription start site

  , PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 107, Pages: 2247-2252, ISSN: 0027-8424
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  • Citations: 53
• Journal article
  Ewens CA, Kloppsteck P, Foerster A, Zhang X, Freemont PSet al., 2010,

  Structural and functional implications of phosphorylation and acetylation in the regulation of the AAA+ protein p97

  , BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE, Vol: 88, Pages: 41-48, ISSN: 0829-8211
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  • Citations: 30
• Journal article
  Chaudhuri RR, Sebaihia M, Hobman JL, Webber MA, Leyton DL, Goldberg MD, Cunningham AF, Scott-Tucker A, Ferguson PR, Thomas CM, Frankel G, Tang CM, Dudley EG, Roberts IS, Rasko DA, Pallen MJ, Parkhill J, Nataro JP, Thomson NR, Henderson IRet al., 2010,

  Complete Genome Sequence and Comparative Metabolic Profiling of the Prototypical Enteroaggregative <i>Escherichia coli</i> Strain 042

  , PLOS ONE, Vol: 5, ISSN: 1932-6203
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  • Citations: 133
• Journal article
  Zunszain PA, Knox SR, Sweeney TR, Yang J, Roque-Rosell N, Belsham GJ, Leatherbarrow RJ, Curry Set al., 2010,

  Insights into Cleavage Specificity from the Crystal Structure of Foot-and-Mouth Disease Virus 3C Protease Complexed with a Peptide Substrate

  , JOURNAL OF MOLECULAR BIOLOGY, Vol: 395, Pages: 375-389, ISSN: 0022-2836
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  • Citations: 53
• Journal article
  Khoo JY, Heng JYY, Williams DR, 2010,

  Agglomeration Effects on the Drying and Dehydration Stability of Pharmaceutical Acicular Hydrate: Carbamazepine Dihydrate

  , INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, Vol: 49, Pages: 422-427, ISSN: 0888-5885
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  • Citations: 12
• Journal article
  Hughes S, Jenkins V, Dar MJ, Engelman A, Cherepanov Pet al., 2010,

  Transcriptional Co-activator LEDGF Interacts with Cdc7-Activator of S-phase Kinase (ASK) and Stimulates Its Enzymatic Activity

  , JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 285, Pages: 541-554
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  • Citations: 50
• Journal article
  Curry S, 2010,

  More light and colour. Science and the new media

  , Biochemist, Vol: 32, Pages: 18-21, ISSN: 0954-982X
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• Journal article
  Thompson O, Moore CJ, Hussaina S-A, Kleino I, Peckham M, Hohenester E, Ayscough KR, Saksela K, Winder SJet al., 2010,

  Modulation of cell spreading and cell-substrate adhesion dynamics by dystroglycan

  , JOURNAL OF CELL SCIENCE, Vol: 123, Pages: 118-127, ISSN: 0021-9533
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  • Citations: 42
• Conference paper
  Robinson T, Manning HB, Dunsby C, Neil MAA, Baldwin GS, de Mello AJ, French PMWet al., 2010,

  Investigating fast enzyme-DNA kinetics using multidimensional fluorescence imaging and microfluidics

  , Conference on Microfluidics, BioMEMS, and Medical Microsystems VIII, Publisher: SPIE-INT SOC OPTICAL ENGINEERING, ISSN: 0277-786X
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  • Citations: 1
• Journal article
  Vittadello M, Gorbunov MY, Mastrogiovanni DT, Wielunski LS, Garfunkel EL, Guerrero F, Kirilovsky D, Sugiura M, Rutherford AW, Safari A, Falkowski PGet al., 2010,

  Photoelectron Generation by Photosystem II Core Complexes Tethered to Gold Surfaces

  , CHEMSUSCHEM, Vol: 3, Pages: 471-475, ISSN: 1864-5631
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  • Citations: 29
• Journal article
  Thomas JC, Green JL, Howson RI, Simpson P, Moss DK, Martin SR, Holder AA, Cota E, Tate EWet al., 2010,

  Interaction and dynamics of the <i>Plasmodium</i> <i>falciparum</i> MTIP-MyoA complex, a key component of the invasion motor in the malaria parasite

  , MOLECULAR BIOSYSTEMS, Vol: 6, Pages: 494-498, ISSN: 1742-206X
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  • Citations: 25
• Journal article
  Ayub M, Ivanov A, Instuli E, Cecchini M, Chansin G, McGilvery C, Hong J, Baldwin G, McComb D, Edel JB, otherset al., 2010,

  Nanopore/electrode structures for single-molecule biosensing

  , Electrochimica Acta, Vol: 55, Pages: 8237-8243
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• Journal article
  Herrero C, Hughes JL, Quaranta A, Cox N, Rutherford AW, Leibl W, Aukauloo Aet al., 2010,

  Intramolecular light induced activation of a Salen-Mn<SUP>III</SUP> complex by a ruthenium photosensitizer

  , CHEMICAL COMMUNICATIONS, Vol: 46, Pages: 7605-7607, ISSN: 1359-7345
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  • Citations: 30
• Journal article
  Roskilly SJ, Colbourn EA, Alli O, Williams DR, Paul KA, Welfare EH, Trusty PAet al., 2010,

  Investigating the effect of shape on particle segregation using aMonte Carlo simulation

  , Powder Technology, Vol: 203, Pages: 211-222

  A Monte Carlo simulation has been used to investigate the segregation potential of a range of particulate systems under conditions in which the particles undergo high amplitude low frequency shaking. These systems involve a wide range of binary powder mixtures in which complex particle shapes have been investigated, including plates and rods which represent the real world materials encountered in pharmaceutical systems such as those which include crystalline components. Previous simulations on the segregation propensity of systems with different shapes were limited to spheres and spherocylinders, with relatively low vibrational amplitude drops. A commercial computer application for particle packing—calledMacroPac—has been successfully employed here, as it has been able to model systems that are more complex where the shape variation is much wider. These simulations apply to the case of macroscopic particles, in the absence of air resistance and inter-particle forces. For non-spherical shapes, an ‘effective size’ which relates to the radius of gyration of the particles is determined. Our studies indicate that with high amplitude low frequency shaking, in a mixture of particles with different shapes but with equal volumes, the particles with the larger ‘effective size’, which tend to have a lower packing fraction, segregate to the top

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• Journal article
  Low HH, Sachse C, Amos LA, Lowe Jet al., 2009,

  Structure of a Bacterial Dynamin-like Protein Lipid Tube Provides a Mechanism For Assembly and Membrane Curving

  , CELL, Vol: 139, Pages: 1342-1352, ISSN: 0092-8674
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  • Citations: 136
• Journal article
  Douzi B, Durand E, Bernard C, Alphonse S, Cambillau C, Filloux A, Tegoni M, Voulhoux Ret al., 2009,

  The XcpV/GspI Pseudopilin Has a Central Role in the Assembly of a Quaternary Complex within the T2SS Pseudopilus

  , JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 284, Pages: 34580-34589
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  • Citations: 51
• Journal article
  Carafoli F, Bihan D, Stathopoulos S, Konitsiotis AD, Kvansakul M, Farndale RW, Leitinger B, Hohenester Eet al., 2009,

  Crystallographic Insight into Collagen Recognition by Discoidin Domain Receptor 2

  , STRUCTURE, Vol: 17, Pages: 1573-1581, ISSN: 0969-2126
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  • Citations: 105
• Journal article
  Eswaran J, Patnaik D, Filippakopoulos P, Wang F, Stein RL, Murray JW, Higgins JMG, Knapp Set al., 2009,

  Structure and functional characterization of the atypical human kinase haspin

  , PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 106, Pages: 20198-20203, ISSN: 0027-8424
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  • Citations: 122
• Journal article
  Nicastro G, Masino L, Esposito V, Menon RP, De Simone A, Fraternali F, Pastore Aet al., 2009,

  Josephin Domain of Ataxin-3 Contains Two Distinct Ubiquitin-Binding Sites

  , BIOPOLYMERS, Vol: 91, Pages: 1203-1214, ISSN: 0006-3525
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  • Citations: 71
• Journal article
  Listorti A, Durrant J, Barber J, 2009,

  ARTIFICIAL PHOTOSYNTHESIS Solar to fuel

  , NATURE MATERIALS, Vol: 8, Pages: 929-U22, ISSN: 1476-1122
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  • Citations: 189
• Journal article
  Bulgin R, Arbeloa A, Goulding D, Dougan G, Crepin VF, Raymond B, Frankel Get al., 2009,

  The T3SS Effector EspT Defines a New Category of Invasive Enteropathogenic <i>E</i>. <i>coli</i> (EPEC) Which Form Intracellular Actin Pedestals

  , PLOS PATHOGENS, Vol: 5, ISSN: 1553-7366
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  • Citations: 42
• Journal article
  De Simone A, Cavalli A, Hsu S-TD, Vranken W, Vendruscolo Met al., 2009,

  Accurate Random Coil Chemical Shifts from an Analysis of Loop Regions in Native States of Proteins

  , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol: 131, Pages: 16332-+, ISSN: 0002-7863
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  • Citations: 78
• Journal article
  Baier J, Gabrielsen M, Oellerich S, Michel H, van Heel M, Cogdell RJ, Koehler Jet al., 2009,

  Spectral Diffusion and Electron-Phonon Coupling of the B800 BChl a Molecules in LH2 Complexes from Three Different Species of Purple Bacteria

  , BIOPHYSICAL JOURNAL, Vol: 97, Pages: 2604-2612, ISSN: 0006-3495
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  • Citations: 22
• Journal article
  Chim N, McMath LM, Beeby M, Goulding CWet al., 2009,

  Advances in Mycobacterium tuberculosis structural genomics: investigating potential chinks in the armor of a deadly pathogen

  , Infect Disord Drug Targets, Vol: 9, Pages: 475-492
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• Journal article
  Bolanos-Garcia VM, Chayen NE, 2009,

  New directions in conventional methods of protein crystallization

  , PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, Vol: 101, Pages: 3-12, ISSN: 0079-6107
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  • Citations: 44
• Journal article
  Hu Y, Guimond SE, Travers P, Cadman S, Hohenester E, Turnbull JE, Kim S-H, Bouloux P-Met al., 2009,

  Novel Mechanisms of Fibroblast Growth Factor Receptor 1 Regulation by Extracellular Matrix Protein Anosmin-1

  , JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 284, Pages: 29905-29920
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  • Citations: 59

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